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Discovery of Salivary Gland Tumors' Biomarkers via Co-Regularized Sparse-Group Lasso

机译:通过共同规整的稀疏组套索发现唾液腺肿瘤的生物标记

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摘要

In this study, we discovered a panel of discriminative microR-NAs in salivary gland tumors by application of statistical machine learning methods. We modelled multi-component interactions of salivary microRNAs to detect group-based associations among the features, enabling the distinction of malignant from benign tumors with a high predictive performance utilizing only seven microRNAs. Several of the identified microRNAs are separately known to be involved in cell cycle regulation. Integrated biological interpretation of identified microRNAs can provide potential new insights into the biology of salivary gland tumors and supports the development of non-invasive diagnostic tests to discriminate salivary gland tumor subtypes.
机译:在这项研究中,我们通过应用统计机器学习方法在唾液腺肿瘤中发现了一组判别性microR-NA。我们对唾液微RNA的多组分相互作用进行建模,以检测特征之间基于基团的关联,从而仅使用七个微RNA就可将恶性肿瘤与良性肿瘤区分开,并具有较高的预测性能。分别已知几种已鉴定的microRNA与细胞周期调控有关。鉴定出的microRNA的整合生物学解释可以为唾液腺肿瘤的生物学研究提供潜在的新见解,并支持开发非侵入性诊断测试来区分唾液腺肿瘤亚型。

著录项

  • 来源
    《Discovery science》|2017年|298-305|共8页
  • 会议地点 Kyoto(JP)
  • 作者单位

    Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center Amsterdam/Cancer Center Amsterdam, Amsterdam, The Netherlands ,Horaizon BV, Rotterdam, The Netherlands;

    Department of Pathology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands ,Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands;

    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands;

    Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center Amsterdam/Cancer Center Amsterdam, Amsterdam, The Netherlands;

    Center for Oral/Head and Neck Oncology Research, University of California Los Angeles, Los Angeles, USA;

    Department of Pathology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands;

    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands;

    Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands ,Horaizon BV, Rotterdam, The Netherlands;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Cancer biomarkers; Salivary gland tumors; Feature selection; Stability selection; Co-regularization; microRNA;

    机译:癌症生物标志物;唾液腺肿瘤;功能选择;稳定性选择;共同规范化;微小RNA;

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