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首页> 外文会议>Dynamics and fluctuations in biomedical photonics XI >In vivo label-free monitoring microvascular and lymphatic vessel changes and dynamics during wound healing in mouse ear pinna using optical microangiography
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In vivo label-free monitoring microvascular and lymphatic vessel changes and dynamics during wound healing in mouse ear pinna using optical microangiography

机译：使用光学微血管造影技术在小鼠耳廓伤口愈合过程中进行无标签体内监测微血管和淋巴管的变化和动力学

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摘要

Cutaneous wound healing consists of multiple overlapping phases starting with blood coagulation following incision of blood vessels. In this paper, we briefly review wound healing phases that were observed by utilizing optical microangiography (OMAG) to monitor healing process and dynamics of microcirculation system in a mouse ear pinna wound model. Mouse ear pinna is composed of two layers of skin separated by a layer of cartilage and because its total thickness is around 500 μm, can be utilized as an ideal model for optical imaging techniques. These skin layers are identical to human skin structure except for sweat ducts and glands. Microcirculatory system responds to the wound injury by recruiting collateral vessels to supply blood flow to hypoxic area. Also, lymphatic vessels play an important role in the immune response of the tissue and clearing waste from interstitial fluid.
机译：皮肤伤口愈合包括多个重叠阶段，这些阶段从切开血管后的凝血开始。在本文中，我们简要回顾了通过使用光学微血管造影（OMAG）监测小鼠耳廓伤口模型中的愈合过程和微循环系统动力学观察到的伤口愈合阶段。鼠耳耳廓由两层被一层软骨隔开的皮肤组成，并且由于其总厚度约为500μm，因此可以用作光学成像技术的理想模型。这些皮肤层与人体皮肤结构相同，除了汗管和腺体。微循环系统通过招募侧支血管为缺氧区域供应血流来对伤口损伤作出反应。而且，淋巴管在组织的免疫反应和清除组织液中的废物中起着重要的作用。

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