• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Dynamics and fluctuations in biomedical photonics XI >Large field-of-view and depth-specific cortical microvascular imaging underlies regional differences in ischemic brain
【24h】

Large field-of-view and depth-specific cortical microvascular imaging underlies regional differences in ischemic brain

机译：大视野和深度特定的皮质微血管成像是缺血性脑区域差异的基础

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ability to non-invasively monitor and quantify of blood flow, blood vessel morphology, oxygenation and tissue morphology is important for improved diagnosis, treatment and management of various neurovascular disorders, e.g., stroke. Currently, no imaging technique is available that can satisfactorily extract these parameters from in vivo microcirculatory tissue beds, with large field of view and sufficient resolution at defined depth without any harm to the tissue. In order for more effective therapeutics, we need to determine the area of brain that is damaged but not yet dead after focal ischemia. Here we develop an integrated multi-functional imaging system, in which SDW-LSCI (synchronized dual wavelength laser speckle imaging) is used as a guiding tool for OMAG (optical microangiography) to investigate the fine detail of tissue hemodynamics, such as vessel flow, profile, and flow direction. We determine the utility of the integrated system for serial monitoring afore mentioned parameters in experimental stroke, middle cerebral artery occlusion (MCAO) in mice. For 90 min MCAO, onsite and 24 hours following reperfusion, we use SDW-LSCI to determine distinct flow and oxygenation variations for differentiation of the infarction, peri-infarct, reduced flow and contralateral regions. The blood volumes are quantifiable and distinct in afore mentioned regions. We also demonstrate the behaviors of flow and flow direction in the arterials connected to MCA play important role in the time course of MCAO. These achievements may improve our understanding of vascular involvement under pathologic and physiological conditions, and ultimately facilitate clinical diagnosis, monitoring and therapeutic interventions of neurovascular diseases, such as ischemic stroke.
机译：非侵入性地监视和量化血流，血管形态，氧合和组织形态的能力对于改善各种神经血管疾病例如中风的诊断，治疗和管理很重要。当前，没有可用的成像技术能够从体内微循环组织床中令人满意地提取这些参数，并且具有大的视野并且在限定的深度具有足够的分辨率而对组织没有任何伤害。为了获得更有效的治疗方法，我们需要确定局灶性缺血后受损但尚未死亡的大脑区域。在这里，我们开发了一个集成的多功能成像系统，其中SDW-LSCI（同步双波长激光散斑成像）用作OMAG（光学微血管造影）的指导工具，以研究组织血液动力学的精细细节，例如血管血流，轮廓和流向。我们确定集成系统的实用程序，用于在小鼠的实验性中风，大脑中动脉闭塞（MCAO）中连续监测上述参数。对于90分钟的MCAO，现场和再灌注后24小时，我们使用SDW-LSCI确定明显的血流和氧合变化，以区分梗死，梗死周围，血流减少和对侧区域。在上述区域中，血容量是可量化的并且是不同的。我们还证明了在连接MCA的动脉中流动和流动方向的行为在MCAO的时间过程中起重要作用。这些成就可能会增进我们对病理和生理条件下血管受累的了解，并最终促进神经血管疾病（例如缺血性中风）的临床诊断，监测和治疗干预。

著录项

  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Jia Qin; Lei Shi; Suzan Dziennis; Ruikang K Wang;

  • 作者单位

    Division of Biomedical Engineering, Department of Automation Engineering, Northeastern University at Qinhuangdao, Hebei 066004, China Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA;

    Division of Biomedical Engineering, Department of Automation Engineering, Northeastern University at Qinhuangdao, Hebei 066004, China Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA;

    Division of Biomedical Engineering, Department of Automation Engineering, Northeastern University at Qinhuangdao, Hebei 066004, China Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA;

    Division of Biomedical Engineering, Department of Automation Engineering, Northeastern University at Qinhuangdao, Hebei 066004, China Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    multi-function; Optical microangiography; laser speckle; hemodynamic; ischemic stroke;

    机译：多功能光学微血管造影；激光斑点血液动力学缺血性中风;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号