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Imaging of electro-kinetic properties of tissue using the amplitude and the phase of optical coherence tomography

机译:使用光学相干断层扫描的振幅和相位对组织的电动特性进行成像

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摘要

The electric field induced optical changes (EIOC) measured by the optical coherence tomography (OCT) reflect the local electro-kinetic properties of the tissue. In this study we developed a method to use the phase of the complex OCT images to map EIOC in tissue samples. Switching the polarity of the electric field induced significant reversible changes in the phase of the complex OCT images. Since the resulting phase was degraded by the noise an advanced signal processing algorithm was developed to obtain the EIOC images. The developed algorithm made it possible to get structural phase images from a standard commercial OCT system, potentially yielding important insights into the local electro-kinetic properties of the tissue. We use a simple theoretical model to simulate main features of amplitude and phase EIOC observed using frequency-domain OCT.
机译:通过光学相干断层扫描(OCT)测量的电场感应光学变化(EIOC)反映了组织的局部电动特性。在这项研究中,我们开发了一种方法,可以使用复杂OCT图像的相位来绘制组织样本中的EIOC。切换电场的极性会导致复杂OCT图像相位发生明显的可逆变化。由于产生的相位由于噪声而退化,因此开发了一种先进的信号处理算法来获取EIOC图像。所开发的算法使从标准的商用OCT系统获得结构相图像成为可能,从而有可能对组织的局部电动特性产生重要的见解。我们使用简单的理论模型来模拟使用频域OCT观察到的振幅和相位EIOC的主要特征。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者单位

    Dept. of Physics, Ryerson University, 50 Gould Street, Toronto, ON, M5B 2K3, Canada;

    Dept. of Physics, Ryerson University, 50 Gould Street, Toronto, ON, M5B 2K3, Canada,Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada;

    Dept. of Physics, Ryerson University, 50 Gould Street, Toronto, ON, M5B 2K3, Canada;

    Dept. of Electrical and Computer Engineering, Ryerson University, 50 Gould Street, Toronto, ON, M5B 2K3, Canada;

    Dept. of Electrical and Computer Engineering, Ryerson University, 50 Gould Street, Toronto, ON, M5B 2K3, Canada,Dept. of Medicine, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada;

    Dept. of Physics, Ryerson University, 50 Gould Street, Toronto, ON, M5B 2K3, Canada,Dept. of Electrical and Computer Engineering, Ryerson University, 50 Gould Street, Toronto, ON, M5B 2K3, Canada;

    Depts. of Medical Biophysics and Radiation Oncology, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    phase; optical coherence tomography; electro-kinetic phenomenon; OCT image processing; optical properties of tissue;

    机译:相;光学相干断层扫描;电动现象OCT图像处理;组织的光学特性;

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