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Characterization of a Putative Hemagglutinin Gene in the Caprine Model for Brucellosis

机译:布鲁氏菌病的小鼠模型中假定的血凝素基因的表征

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摘要

With the completion of the genomic sequences of Brucella melitensis 16M and B. abortus 2308 and the vaccine strain RB51, a putative hemagglutinin gene was identified that is present in 16M and absent in B. abortus. The possibility of this hemagglutinin being a potential host specificity factor was evaluated via expression in trans in B. abortus 2308-QAE and RB51-QAE. Using the caprine brucellosis model, colonization and pathogenesis studies were performed to evaluate the strains.
机译:随着布鲁氏菌16M和流产布鲁氏菌2308和疫苗菌株RB51的基因组序列的完成,鉴定出假定的血凝素基因存在于16M中,而在流产布鲁氏菌中不存在。通过在流产芽孢杆菌2308-QAE和RB51-QAE中反式表达来评估这种血凝素作为潜在宿主特异性因子的可能性。使用山羊布鲁氏菌病模型,进行了定植和发病机理研究,以评估菌株。

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  • 来源
  • 会议地点 Tbilisi GA(US)
  • 作者单位

    Department of Pathobiological Sciences, School of Veterinary Medicine,Louisiana State University, Baton Rouge, Louisiana;

    rnDepartment of Veterinary Science, Louisiana State University Agricultural Center,Baton Rouge, Louisiana;

    rnDepartment of Veterinary Science, Louisiana State University Agricultural Center,Baton Rouge, Louisiana;

    rnDepartment of Pathobiological Sciences, School of Veterinary Medicine,Louisiana State University, Baton Rouge, Louisiana;

    rnDepartment of Pathobiological Sciences, School of Veterinary Medicine,Louisiana State University, Baton Rouge, Louisiana Department of Veterinary Science, Louisiana State University Agricultural Center,Baton Rouge, Louisiana;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 流行病学与防疫;地方病学;
  • 关键词

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