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首页> 外文会议>Endoscopic microscopy X; and Optical Techniques in Pulmonary Medicine II >Low cost and compact nonlinear (SHG/TPE) laser scanning endoscope for bio-medical application
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Low cost and compact nonlinear (SHG/TPE) laser scanning endoscope for bio-medical application

机译：低成本，紧凑型非线性（SHG / TPE）激光扫描内窥镜，用于生物医学应用

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摘要

Two-photon fluorescence (TPE) and second harmonic generation (SHG) can been used to extract biological information from tissues at the molecular level, which is blind to traditional microscopes. Through these two image contrast mechanisms, a nonlinear laser scanning endoscope (NLSE) is able to image tissue cells and the extra cellular matrix (ECM) through a special fiber and miniaturized scanner without the requirement of poisonous chemical staining. Therefore, NLSE reserves high potential for in-vivo pathological study and disease diagnosis. However, the high cost and bulky size of a NLSE system has become one of the major issues preventing this technology from practical clinical operation. In this paper, we report a fiber laser based multi-modality NLSE system with compact size and low cost, ideal for in-vivo applications in clinical environments. The demonstration of the developed NLSE nonlinear imaging capability on different bio-structures in liver, retina and skin are also presented.
机译：可以使用双光子荧光（TPE）和二次谐波（SHG）从分子水平上从组织中提取生物信息，这是传统显微镜所看不到的。通过这两种图像对比机制，非线性激光扫描内窥镜（NLSE）可以通过特殊的纤维和小型扫描仪对组织细胞和细胞外基质（ECM）进行成像，而无需进行有毒的化学染色。因此，NLSE在体内病理学研究和疾病诊断方面具有很高的潜力。但是，NLSE系统的高成本和体积庞大已成为阻碍该技术进行实际临床操作的主要问题之一。在本文中，我们报告了一种基于光纤激光器的多模态NLSE系统，具有紧凑的尺寸和低成本，非常适合临床环境中的体内应用。还展示了已开发的NLSE非线性成像功能在肝脏，视网膜和皮肤上不同生物结构上的演示。

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