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Practical pathology for thermal tissue applications

机译：热组织应用的实用病理学

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The development of minimally invasive medical devices, which employ hyperthermic and/or cryothermic modalities to treat a variety of organ system diseases, is a rapidly expanding field. Consultation with a knowledgeable pathologist during the development of these devices is crucial, as characterization of the treated tissues can support the device's safety and future efficacy. The properties of thermally treated tissues often share a set of overlapping histopathologic characteristics, regardless of organ system. Several methods for optimally evaluating these thermal changes have been developed that depend on the tissue's post-treatment time interval. For devices associated with hyperthermic collagen denaturation, bright field or polarized light microscopy of hematoxylin and eosin stained sections can be utilized to assess thermal spread within the tissue. For applications resulting in collagen denaturation with associated desiccation, trichrome staining may provide additional information. For cryothermic devices, these collagen-based methods are generally less informative. Tetrazolium-based tissue viability staining (triphenyltetrazolium chloride, TTC; nitroblue tetrazolium, NBT; NADH/NADPH staining) can be used to assess for the presence of associated tissue necrosis within either hyperthermically or cryothermically treated tissues. The advantages and limitations of several of these methods will be discussed.
机译：使用高温和/或低温方式治疗各种器官系统疾病的微创医疗设备的发展是一个迅速扩展的领域。在开发这些设备时，与经验丰富的病理学家进行协​​商非常重要，因为治疗组织的表征可以支持该设备的安全性和未来的功效。不论器官系统如何，经过热处理的组织的属性通常都具有一组重叠的组织病理学特征。已经开发了几种最佳评估这些热变化的方法，这些方法取决于组织的治疗后时间间隔。对于与高温胶原蛋白变性相关的设备，苏木精和曙红染色切片的明场或偏光显微镜可用于评估组织内的热扩散。对于导致胶原蛋白变性和相关脱水的应用，三色染色可能会提供其他信息。对于低温设备，这些基于胶原蛋白的方法通常提供的信息较少。基于四氮唑的组织生存力染色（三苯基氯化四氮唑，TTC；硝基蓝四氮唑，NBT； NADH / NADPH染色）可用于评估在高温或低温治疗的组织中相关组织坏死的存在。将讨论其中几种方法的优缺点。

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