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首页> 外文会议>Energy-based treatment of tissue and assessment VIII >Development of a fast 3D treatment planning platform for clinical interstitial microwave hyperthermia within free-hand obliquely implanted HDR catheters
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Development of a fast 3D treatment planning platform for clinical interstitial microwave hyperthermia within free-hand obliquely implanted HDR catheters

机译：在徒手倾斜植入的HDR导管内开发用于临床间质性微波热疗的快速3D治疗计划平台

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摘要

A treatment planning platform for interstitial microwave hyperthermia was developed for practical, free-hand clinical implants. Such implants, consisting of non-parallel, moderately curved antennas with varying insertion depths, are used in HDR brachytherapy for treating locally advanced cancer. Numerical models for commercially available MA251 antennas (915 MHz, BSD Medical) were developed in COMSOL Multiphysics, a finite element analysis software package. To expedite treatment planning, electric fields, power deposition and temperature rises were computed for a single straight antenna in 2D axisymmetric geometry. A pre-computed library of electric field and temperature solutions was created for a range of insertion depths (5-12 cm) and blood perfusion rates (0.5-5 kg/m~3/s). 3D models of multiple antennas and benchtop phantoms experiments using temperature-sensitive liquid crystal paper to monitor heating by curved antennas were performed for comparative evaluation of the treatment planning platform. A patient-customizable hyperthermia treatment planning software package was developed in MATLAB with capabilities to interface with a commercial radiation therapy planning platform (Oncentra, Nucleotron), import patient and multi-catheter implant geometries, calculate insertion depths, and perform hyperthermia planning with antennas operating in asynchronous or synchronous mode. During asynchronous operation, the net power deposition and temperature rises were approximated as a superposition sum of the respective quantities for one single antenna. During synchronous excitation, a superposition of complex electrical fields was performed with appropriate phasing to compute power deposition. Electric fields and temperatures from the pre-computed single-antenna library were utilized following appropriate non-rigid coordinate transformations. Comparison to 3D models indicated that superposition of electric fields around parallel antennas is valid when they are at least 15 mm apart. Phantom experiments with curved antennas produced temperature profiles quite similar to those created using the planning system. The hyperthermia planning software allowed users to select power and phasing, assess the corresponding 3D contours of energy and temperature, and optimize treatment parameters through gradient search techniques. The system produces fairly accurate temperature distributions in cases when the antennas are at least 15 mm apart.
机译：为实用的徒手临床植入物开发了间质性微波热疗的治疗计划平台。这种植入物由具有不同插入深度的不平行，适度弯曲的天线组成，用于HDR近距离放射治疗中以治疗局部晚期癌症。在有限元分析软件包COMSOL Multiphysics中开发了可商购的MA251天线（915 MHz，BSD Medical）的数值模型。为了加快治疗计划，针对二维轴对称几何中的单个直天线计算了电场，功率沉积和温度上升。针对插入深度（5-12 cm）和血液灌注速率（0.5-5 kg / m〜3 / s）的范围，创建了预先计算的电场和温度溶液库。进行了多天线3D模型和台式体模实验，使用热敏液晶纸监测弯曲天线的热量，以比较评估治疗计划平台。在MATLAB中开发了患者可自定义的高温治疗计划软件包，该软件包可与商业放射治疗计划平台（Oncentra，Nucleotron）对接，导入患者和多导管植入物的几何形状，计算插入深度，并通过操作天线进行高温计划在异步或同步模式下。在异步操作期间，净功率沉积和温度升高近似为一个天线的各个量的叠加总和。在同步激励期间，通过适当的相位执行复杂电场的叠加以计算功率沉积。在适当的非刚性坐标转换之后，利用来自预先计算的单天线库的电场和温度。与3D模型的比较表明，平行天线周围的电场重叠至少相距15毫米是有效的。使用弯曲天线的幻影实验产生的温度曲线与使用计划系统创建的温度曲线非常相似。热疗计划软件允许用户选择功率和相位，评估能量和温度的相应3D轮廓，并通过梯度搜索技术优化治疗参数。如果天线之间的距离至少为15 mm，则该系统会产生相当准确的温度分布。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Serena J. Scott; Vasant A. Salgaonkar; Punit Prakash; Sergio Curto; I-Chow Hsu; Chris J. Diederich;

  • 作者单位

    Dept. of Radiation Oncology, University of California, San Francisco, 1600 Divisadero St., Suite H-1031, San Francisco, CA 94143;

    Dept. of Radiation Oncology, University of California, San Francisco, 1600 Divisadero St., Suite H-1031, San Francisco, CA 94143;

    Department of Electrical and Computer Engineering, Kansas State University, Manhattan, KS, USA;

    Department of Electrical and Computer Engineering, Kansas State University, Manhattan, KS, USA;

    Dept. of Radiation Oncology, University of California, San Francisco, 1600 Divisadero St., Suite H-1031, San Francisco, CA 94143;

    Dept. of Radiation Oncology, University of California, San Francisco, 1600 Divisadero St., Suite H-1031, San Francisco, CA 94143;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Microwave; hyperthermia; treatment planning; numerical model;

    机译：微波;热疗;治疗计划；数值模型;

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