• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Environmental and food safety and security for south-east Europe and Ukraine. >Environmental and Drug Induced Renal Damage; The Way to Protect
【24h】

Environmental and Drug Induced Renal Damage; The Way to Protect

机译：环境和药物引起的肾脏损害；保护方式

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Kidneys are targets of numerous toxicants due to anatomical, physiological and biochemical features of the organs. Factors contributing to the sensitivity of kidneys include large blood flow, presence of a variety of transporters, a lot of functionally necessary metabolizing enzymes, etc. This paper reviews some mechanisms of nephrotoxic action of widely distributed metal compounds and of an anticancer drug cisplatin as a model of drug induced renal damage. Cisplatin is known to induce nephropathy that is restricted primarily to the S_3, segment of the proximal tubule, with involvement of S_2, and S_1 segments at higher doses. This particularity appears to be derived from the distribution of enzymes and transport proteins important for uptake of cisplatin into proximal tubule cells: apical γ-glutamyltranspepti-dase and the basolateral organic anion transport system. Regional distributions of transport mechanisms for binding proteins appear to be important in the expression of nephrotoxicity of cisplatin. According to the mechanism of damage the way to protect is proposed with application of antioxidants and mighty antioxidants such as cluster rhenium compounds with organic ligands that contain an unique quadruple bond are demonstrated as nephroprotectors in the model of tumor growth and cisplatin application.
机译：由于器官的解剖，生理和生化特征，肾脏是多种有毒物质的靶标。导致肾脏敏感的因素包括大血流量，多种转运蛋白的存在，功能上必需的许多代谢酶等。本文概述了广泛分布的金属化合物和抗癌药顺铂作为一种药物的肾毒性作用的一些机制。药物引起的肾损伤模型。已知顺铂诱导的肾病主要限于近端小管的S_3段，并伴随较高剂量的S_2和S_1段。这种特殊性似乎源自酶和转运蛋白的分布，这些酶和转运蛋白对顺铂向近端小管细胞的吸收很重要：顶端的γ-谷氨酰转肽酶和基底外侧有机阴离子转运系统。结合蛋白的转运机制的区域分布似乎在顺铂肾毒性的表达中很重要。根据损伤的机理，提出了使用抗氧化剂的保护方法，并在肿瘤生长和顺铂应用模型中证明了强大的抗氧化剂，例如带有有机配体的簇rh化合物具有独特的四重键，作为肾保护剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号