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The History, Toxicity and Adverse Human Health and Environmental Effects Related to the Use of Agent Orange

机译:与使用橘子剂相关的历史,毒性和不良的人类健康与环境影响

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Agent Orange consist of 50 % n-butyl esters of 2,4,5-trichlorophenoxy acetic acid and 50 % 2,4-dichlorophenoxyacetic acid. These compounds are chemical plant growth regulators, which mimic the effect of plant hormones, provoking plants into frantic growth before they wither and die. The toxicity of Agent Orange is attributed to the contamination with dioxin, which was perhaps the most toxic molecule ever synthesized by man. Agent Orange's actual effect on human health remained controversial because even though dioxin at certain levels was clearly capable of causing serious diseases, those same diseases could also result from other causes. Dioxin is a persistent organic pollutant that will accumulate in animal fat and plant tissues and therefore can enter the food chain. The US National Toxicology Program has classified dioxin as "known to be a human carcinogen", causing namely, chronic lymphocytic leukemia, soft tissue sarcoma, non-Hodgkin lymphoma and Hodgkin disease with sufficient evidence of an association. Severe acute intoxication of dioxin caused chloracne, porphyria, transient hepatotoxicity, and neurotoxicity. Chronic persistence of dioxin in the human body may contribute to development of atherosclerosis, hypertension, diabetes, vascular changes, and neuropsychological impairment several decades after massive exposure. However, such chronic effects are nonspecific and multifactorial. This paper elaborates the aforementioned and other health effects of Agent Orange.
机译:剂橙由50%的2,4,5-三氯苯氧基乙酸正丁酯和50%的2,4-二氯苯氧基乙酸组成。这些化合物是化学植物生长调节剂,其模仿植物激素的作用,促使植物在凋谢和死亡之前疯狂生长。橙剂的毒性归因于二恶英的污染,二恶英可能是人类合成的最具毒性的分子。橙剂对人类健康的实际影响仍然存在争议,因为尽管一定水平的二恶英显然能够引起严重的疾病,但同样的疾病也可能是由其他原因引起的。二恶英是一种持久性有机污染物,会在动物脂肪和植物组织中积累,因此可以进入食物链。美国国家毒理学计划已将二恶英列为“已知为人类致癌物”,引起慢性淋巴细胞性白血病,软组织肉瘤,非霍奇金淋巴瘤和霍奇金病,并有充分的证据。二恶英的严重急性中毒会导致十氯痤疮,卟啉症,短暂性肝毒性和神经毒性。人体中二恶英的长期持续存在可能会导致大量接触数十年后动脉粥样硬化,高血压,糖尿病,血管变化和神经心理损害。但是,这种慢性影响是非特异性和多因素的。本文阐述了橘子剂的上述和其他健康影响。

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