MICRO AND NANO THIN FILM DEVICES AS BIO-ASSAYS FOR CANCER DIAGNOSIS

机译：微型和纳米薄膜设备作为癌症诊断的生物检测

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Micro and nano Au/Cr and Al thin film devices have been fabricated using DC sputtering and e-beam evaporation in combination with e-beam and photo lithography. These devices can be coated with specific reagents to detect and measure the presence of particular antigens and/or complementary DNA sequences with a smaller sample size and at much earlier stages of disease progression compared to current medical diagnostic technologies. Using the device material stack (Au/Cr/Si), we have assessed the binding affinity of Au, Cr, and Si with Protein G, and antibodies for Prostate Specific Antigen (PSA) and Cancer Antigen 125 (CA125), an ovarian cancer-associated antigen. Based on our experiments, we see that the thin gold layer of the Au/Cr/Si samples, provides increased bio-material binding affinity, and the chromium layer has a similar, if not less, binding affinity compared to the silicon chip alone.

机译：使用直流溅射和电子束蒸发结合电子束和光刻技术制造了微米级和纳米级Au / Cr和Al薄膜器件。与当前的医学诊断技术相比，这些设备可以用特定的试剂包被，以检测和测量特定抗原和/或互补DNA序列的存在，并以较小的样本量以及在疾病发展的更早期阶段进行检测。使用设备材料堆栈（Au / Cr / Si），我们评估了Au，Cr和Si与蛋白质G的结合亲和力以及针对前列腺特异性抗原（PSA）和卵巢癌125（CA125）抗体（卵巢癌）的抗体-相关抗原。根据我们的实验，我们发现Au / Cr / Si样品的金薄层提供了增强的生物材料结合亲和力，而铬层与单独的硅芯片相比具有相似的结合亲和力，即使不是更少。

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来源
《EPP-vol.6; American Society of Mechanical Engineers(ASME) International Mechanical Engineering Congress and Exposition; 20061105-10; Chicago,IL(US)》|2006年|P.209-214|共6页
会议地点 ChicagoIL(US)
作者
Kevin M. Klein; Gregory T. Ostrowicki; Andrew Gewirtz; Suresh K. Sitaraman;
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作者单位

Computer-Aided Simulation of Reliability (CASPaR) Laboratory The George W. Woodruff Packaging School of Mechanical Engineering Georgia Institute of Technology, Atlanta, GA 30332-0405;

School of Medicine, Emory University, Atlanta, GA;

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会议组织
原文格式 PDF
正文语种 eng
中图分类半导体器件制造工艺及设备;
关键词
bio-assay; mass sensor; piezoelectric; nanolithography cancer diagnosis;

机译：生物测定；质量传感器；压电；纳米光刻术；癌症诊断;
入库时间 2022-08-26 13:47:30

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MICRO AND NANO THIN FILM DEVICES AS BIO-ASSAYS FOR CANCER DIAGNOSIS

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