THE ISOLATION AND ANALYSIS OF DIHYDROPTERI-DINE REDUCTASE

机译：二氢蝶呤还原酶的分离与分析

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Dihydropteridine reductase (DHPR) , catalyzes the reduction of quinonoid dihydropteri-dine back to tetrahydrobiopterin. It is also essemtial for the biosynthesis of dopoamine and serotonin. Patients lacking the reductase would be expected to have not only the symptoms of classic PKU , but also the progressive neurological degeneration due to the severe impairment in the biosynthesis of these netrotransmitters.

机译：二氢蝶呤还原酶（DHPR）催化将醌类二氢蝶呤还原为四氢生物蝶呤。它对多巴胺和5-羟色胺的生物合成也是至关重要的。缺乏还原酶的患者不仅会出现经典的PKU症状，而且由于这些net递质的生物合成受到严重损害，还会出现进行性神经变性。

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来源
《First international symposium on bioanalytical chemistry》|1995年|130-131|共2页
会议地点 Xian(CN);Xian(CN)
作者
Zhenhua Chen; Jiping He; Qin Chen; Bifang Xiong; Rong-sen Shen;
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作者单位

Dept. of Chem, Wuhan Univ, Wuhan 430072, China;

Centre of Research and Analysis of Material, Wuhan Univ. of Tech. , Wuhan 430070, China;

The Second Affiliateel Hospital of Hubei Medical University, Wuhan 430071, China;

Wuhan Third Hospital, Wuhan 430060,China;

Dept. Human Biolog. Chem. . Genet, Univ. Texas Medical Branch, Galveston, TX 77555-0652, U.S.A.;

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THE ISOLATION AND ANALYSIS OF DIHYDROPTERI-DINE REDUCTASE

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