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Feasibility of using ultrasound transmission for image-guided therapy

机译:使用超声传输进行图像引导治疗的可行性

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摘要

Transmission acoustic imaging situates an object between a source and receiver to provide a linear projection of its attenuation properties. The principle has been applied to develop orthographic images to produce two-dimensional image reconstructions. A number of studies have revealed the potential of transmission techniques in medical imaging for recording the attenuation properties of varying tissues. The present study examines the possibility of using transmission imaging to guide thermal therapies. We hypothesize that imaging thermally coagulated tissue with transmission ultrasound can achieve a higher signal to noise ratio than backscattered ultrasound, due to a strong change in attenuation coefficient and relatively low reflection coefficient. We also search for localized change in image intensity due to speed of sound variation caused by temperature changes, thus allowing the ultrasound focal region to be identified. Specifically, we test the transmission method with the acoustic camera system (ⅰ) for its ability to image coagulated tissue, (ⅱ) the ability to identify the focus of a therapeutic ultrasound field in ex vivo tissue samples during sonication, and (ⅲ) for correlation between image intensity and tissue temperature.
机译:传输声成像将一个物体置于源和接收器之间,以提供其衰减特性的线性投影。该原理已应用于显影正交图像以产生二维图像重建。大量研究揭示了医学成像中传输技术用于记录不同组织的衰减特性的潜力。本研究检查了使用透射成像来指导热疗的可能性。我们假设,由于衰减系数的强烈变化和相对较低的反射系数,利用透射超声对热凝组织成像可以实现比背向散射超声更高的信噪比。我们还搜索由于温度变化引起的声音变化速度而引起的图像强度的局部变化,从而可以识别超声聚焦区域。具体来说,我们使用声学相机系统测试传输方法(ⅰ)对凝固组织成像的能力,(ⅱ)在超声处理期间识别离体组织样本中治疗性超声场焦点的能力,以及(ⅲ)图像强度与组织温度之间的相关性。

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