首页> 外文会议>Frontiers in modern carbohydrate chemistry >Chapter 16 The Chemical Synthesis of Glycosylphosphatidylinositol Anchors from Trypanosoma cruzi Trypomastigote Mucins: Exploration of Ester and Acetal Type Permanent Protecting Groups

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Chapter 16 The Chemical Synthesis of Glycosylphosphatidylinositol Anchors from Trypanosoma cruzi Trypomastigote Mucins: Exploration of Ester and Acetal Type Permanent Protecting Groups

机译：第十六章从克氏锥虫Trymasmastigote粘蛋白化学合成糖基磷脂酰肌醇锚定物：酯和乙缩醛型永久保护基团的探索

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The protozoan parasite Trypanosoma cruzi is a causative agent of Chagas' disease, which affects millions of people in South and Central America. Throughout the life cycle, T. cruzi produce both common and stage-specific glycosylphosphatidylinositol(GPI)-anchored cell-surface macromolecules. The purified GPI fraction of T. cruzi trypomastigote mucins (tGPI) revealed extraordinary pro-inflammatory activity (comparable to those of bacterial lipopolysaccharide), which was allegedly associated with the presence of unsaturated fatty acids in the lipid moiety (structures 1 and 2). Two distinct novel synthetic strategies, both implicating the use of non-benzyl type protecting groups, were designed and applied for the chemical preparation of the tGPIs 1 and 2.

机译：原生动物寄生虫克氏锥虫是南美锥虫病的病原体，南美锥虫病影响南美和中美洲的数百万人。在整个生命周期中，克鲁维酵母产生共同和阶段特定的糖基磷脂酰肌醇（GPI）锚定的细胞表面大分子。纯化的克氏锥虫锥虫伪狂犬病粘蛋白（tGPI）的GPI组分显示出非凡的促炎活性（与细菌脂多糖相比），据称与脂质部分中不饱和脂肪酸的存在有关（结构1和2）。设计了两种不同的新颖合成策略，均涉及使用非苄基型保护基，并将其应用于tGPI 1和2的化学制备。

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来源
《Frontiers in modern carbohydrate chemistry》|2005年|285-306|共22页
会议地点 San Diego CA(US);San Diego CA(US)
作者
Dmitry V. Yashunsky; Vladimir S. Borodkin; Philip G. McGivern; Michael A. J. Ferguson; Andrei V. Nikolaev;
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Division of Biological Chemistry and Molecular Microbiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom;

rnDivision of Biological Chemistry and Molecular Microbiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom;

rnDivision of Biological Chemistry and Molecular Microbiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom;

rnDivision of Biological Chemistry and Molecular Microbiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom;

rnDivision of Biological Chemistry and Molecular Microbiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom;

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正文语种 eng
中图分类基本有机化学工业;
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1. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages. [J] . M M Camargo, I C Almeida, M E Pereira, The journal of immunology . 1997,第12期

机译：分离自克鲁斯锥虫锥虫的糖基磷脂酰肌醇固定的粘蛋白样糖蛋白可通过巨噬细胞启动促炎细胞因子的合成。
2. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages. [J] . Coelho PS, Klein A, Talvani A, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2002,第5期

机译：从克鲁斯锥虫锥虫鞭毛体分离的糖基磷脂酰肌醇固定的粘蛋白样糖蛋白诱导体内白细胞募集，这依赖于IFN-γ引发的巨噬细胞产生的MCP-1。
3. Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes [J] . Catherine Ropert, Ludmila R. P. Ferreira, Marco A. S. Campos, Microbes and infection . 2002,第9期

机译：糖蛋白磷脂酰肌醇锚定的粘蛋白样糖蛋白从克鲁斯锥虫Trypomastigotes衍生的巨噬细胞信号。
4. GPIomics: Global Analysis of Glycosylphosphatidylinositol (GPI) Anchors of Trypanosoma cruzi [C] . Nakayasu E.S., Yashunsky D.S., Nohara L.L., American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：GPIOMICS：糖基磷脂酰肌醇（GPI）锚杆的全局分析促蛋白酶瘤Cruzi
5. Synthesis of L. Major Derived Carbohydrate Chemical Probes and a Polydivergently Protected High-Mannose Type N-Glycan Core Pentasaccharide [D] . Rintelmann, Chelsea Lynnette. 2020

机译：L.主要衍生碳水化合物化学探针的合成及多元保护的高甘露糖型N-聚糖芯戊二糖
6. Purification of glycosylphosphatidylinositol-anchored mucins from Trypanosoma cruzi trypomastigotes and synthesis of α-Gal-containing neoglycoproteins: application as biomarkers for reliable diagnosis and early assessment of chemotherapeutic outcomes of Chagas disease [O] . Uriel Ortega-Rodriguez, Susana Portillo, Roger A. Ashmus, -1

机译：克氏锥虫锥虫的糖基磷脂酰肌醇固定的粘蛋白的纯化和含α-Gal的新糖蛋白的合成：作为生物标记物的用途可用于可靠诊断和早期评估南美锥虫病的化学治疗结果
7. The lipid structure of the glycosylphosphatidylinositol-anchored mucin-like sialic acid acceptors of Trypanosoma cruzi changes during parasite differentiation from epimastigotes to infective metacyclic trypomastigote forms. [O] . Serrano, Alvaro Acosta, Schenkman, Sergio, Yoshida, Nobuko, 1995

机译：克氏锥虫的糖基磷脂酰肌醇固定的粘蛋白样唾液酸受体的脂类结构在寄生虫分化过程中从表鞭毛体向感染性间环锥虫的形式变化。

Chapter 16 The Chemical Synthesis of Glycosylphosphatidylinositol Anchors from Trypanosoma cruzi Trypomastigote Mucins: Exploration of Ester and Acetal Type Permanent Protecting Groups

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