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首页> 外文会议>Functional imaging and modeling of the heart >The Purkinje System and Cardiac Geometry: Assessing Their Influence on the Paced Heart
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The Purkinje System and Cardiac Geometry: Assessing Their Influence on the Paced Heart

机译：Purkinje系统和心脏几何：评估其对心脏起搏的影响

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Whole heart computer models are being widely used to assess treatment planning like Cardiac Resynchronization Therapy (CRT), a recognized treatment for heart failure. Certain aspects like cardiac geometry and the Purkinje system (PS) are still sometimes neglected on the studies. The present study includes a model of the human ventricles with incorporated anatomical structures such as myofibers orientation and Purkinje system. Two meshes representative of hypertrophic and dilated cardiomyopathies were generated from an original healthy subject mesh. In the context of (III) atrio-ventricular (AV) block, a sequential pacing protocol was tested for different device configurations. The pacing protocols were performed in models including the PS and in models lacking the PS. The results show that the Purkinje System leads to the synchronization of the septum and the left ventricle (LV) lateral wall, thus minimizing the interventricular delay. Also the modifications in the geometry resulted in changes in the activation patterns of the LV lateral wall, differing notably from physiological scenario.
机译：全心计算机模型被广泛用于评估治疗计划，例如心脏再同步治疗（CRT），这是一种公认​​的心力衰竭治疗方法。某些方面，例如心脏的几何形状和浦肯野系统（PS）有时在研究中仍被忽略。本研究包括具有合并的解剖结构，例如肌纤维取向和浦肯野系统的人体心室模型。从原始的健康受试者网格生成代表肥大性和扩张型心肌病的两个网格。在（III）房室（AV）块的情况下，针对不同的设备配置测试了顺序起搏协议。起搏协议是在包括PS的模型和没有PS的模型中执行的。结果表明，Purkinje系统导致间隔和左心室（LV）侧壁的同步，从而最大程度地减少了心室延迟。同样，几何形状的改变导致LV侧壁激活模式的改变，这与生理情况明显不同。

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