DIFFERENCES IN THE INDUCTION OF APOPTOSIS AFTER TREATMENT WITH γ-IRRADIATION AND C2-CERAMIDE

机译：γ射线和C2-铈酰胺处理后细胞凋亡诱导的差异。

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

Cell death in organisms can be caused by two distinct mechanism: apoptosis and necrosis. These two processes were studied in human leukemic cell lines HL-60 and U-937 after exposure to γ-radiation (6 Gy) and C2-ceramide (μM). Apoptosis was induced by C2-ceramide treatment in both cell lines, whereas after γ-irradiation it was detected only in U-937 cells, wheras HL-60 cells died by necrosis. The different behaviour of U-937 and HL-60 cells is apparently caused by differences in expression of some protoonco-genes in the two cell lines. Two different apoptotic pathways may exist: one, observed only after the exposure to C2-ceramide, is ceramide-induced apoptosis and the other, observed after γ-radiation treatment, is p53-dependent.

机译：生物体内的细胞死亡可能由两种不同的机制引起：细胞凋亡和坏死。在暴露于γ射线（6 Gy）和C2-神经酰胺（μM）后，在人白血病细胞HL-60和U-937中研究了这两个过程。通过C2-神经酰胺处理在两种细胞系中诱导凋亡，而在γ-射线照射后仅在U-937细胞中检测到，而HL-60细胞则因坏死而死亡。 U-937和HL-60细胞的不同行为显然是由两种细胞系中某些原癌基因表达的差异引起的。可能存在两种不同的凋亡途径：一种是仅在暴露于C2-神经酰胺后观察到的，是神经酰胺诱导的凋亡，另一种是在γ射线处理后观察到的，是p53依赖性的。

著录项

来源
《Fundamentals for the assessment of risks from environmental radiation》|1997年|301-304|共4页
会议地点 Brno(CS)
作者
E. BARTOVA; A. SPANOVA;
展开▼
作者单位

Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic;

Department of Microbiology, Faculty of Sciences, Masaryk University, Brno, Czech Republic;

展开▼
会议组织
原文格式 PDF
正文语种 eng
中图分类辐射事故;
关键词

相似文献

外文文献
中文文献
专利

1. γ-射线诱导胆管癌细胞凋亡致敏树突状细胞后的免疫应答 [J] . 吴刚, 顾红光, 韩本立, 癌症（英文版） . 2001,第007期
2. Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. [J] . Chiu HW, Lin JH, Chen YA, Autophagy . 2010,第3期

机译：通过诱导自噬和凋亡，三氧化二砷和放射的联合治疗在体外和体内增强了人纤维肉瘤细胞的细胞杀伤作用。
3. In vitro evaluation of ~(213)Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage [J] . Katia Vandenbulcke, Filip De Vos, Fritz Offner, European journal of nuclear medicine . 2003,第10期

机译：〜（213）Bi-利妥昔单抗与体外伽马射线照射对B-CLL患者的体外评价：关于凋亡诱导和染色体损伤的相对生物学功效
4. Apoptosis induction in peripheral leukemia cells by remission induction treatment in vivo: selective depletion and apoptosis in a CD34|[plus]| subpopulation of leukemia cells [J] . K Stahnke, S Eckhoff, A Mohr, Leukemia . 2003,第11期

机译：体内缓解诱导治疗诱导外周血白血病细胞凋亡：CD34 | +的选择性耗竭和凋亡白血病细胞亚群
5. DIFFERENCES IN THE INDUCTION OF APOPTOSIS AFTER TREATMENT WITH γ-IRRADIATION AND C2-CERAMIDE [C] . NATO advanced research workshop on fundamentals for the assessment of risks from environmental radiation . 1999

机译：用γ-辐照处理后诱导细胞凋亡的差异，C2-神经酰胺
6. TLR4/MyD88 Signaling Activates Ultraviolet Irradiation-Induced Apoptosis: Outcomes and Consequences. [D] . Harberts, Erin Marie. 2014

机译：TLR4 / MyD88信号激活紫外线照射诱导的细胞凋亡：结果和后果。
7. Tumor induction in mice following localized single or fractionated dose irradiation: differences in tumor histotype and genetic susceptibility based on dose scheduling [O] . Elijah F. Edmondson, Nancy R. Hunter, Michael M. Weil, -1

机译：局部或单次剂量照射后小鼠的肿瘤诱导：基于剂量计划的肿瘤组织类型和遗传易感性差异
8. Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis [O] . Hui-Wen Chiu, Jing-Hua Lin, Yi-An Chen, 2010

机译：通过诱导自噬和细胞凋亡，用砷的三氧化砷和辐射的组合治疗在体外和体内提高人类纤维肉瘤细胞中的细胞杀伤作用
9. Effects of Whole Body X-Irradiation of Cyclophosphamide Treatment on Induction of Macrophage Tumoricidal Function in Mice [R] . Schultz, R. M., Pavlidis, N. A., Chirigos, M. A., 1978

机译：全身X射线照射环磷酰胺对小鼠巨噬细胞杀瘤功能的影响

DIFFERENCES IN THE INDUCTION OF APOPTOSIS AFTER TREATMENT WITH γ-IRRADIATION AND C2-CERAMIDE

摘要

著录项

相似文献

相关主题

期刊订阅