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首页> 外文会议>ICA;Conference on independent component analyses, wavelets, neural networks, biosystems, and nanoengineering VII; 20090413-17;20090413-17; Orlando, FL(US);Orlando, FL(US) >Con_A-Carbone Nanotube conjugate with Short Wave near-Infrared laser ablation for tumor therapy
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Con_A-Carbone Nanotube conjugate with Short Wave near-Infrared laser ablation for tumor therapy

机译：Con_A-碳纳米管结合短波近红外激光消融治疗肿瘤

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Using the characteristics of T cell mitogen called lectin protein from the jack-beam Canavalia ensiformis Concanavalin A (Con_A) with dual activities, cytotoxicity and immunomodulation, we have shown it has a therapeutic effect on hepatoma. Injection of ConA can eradicate the established malign tumor, because ConA can induce tumor cell autophagic, cell-programmed death, as well as activate the effector T cells. Combined, in this paper, with the absorption exceeding the Carbon NanoTube (CNT) band-gap (ε_(bg)=～1/CNT diameter) with an active short wave near-infrared (SWIR) (1.2～1.5 micron wavelengths), which happened to be translucent to the irradiation upon animal skin, similar to that used in hospital fingertip-clamped Pulse Oxymetry. Once the ConA-CNT is guided to hepatoma cells, it is bonded and internalized into the mitochondria (MC) compartment, the cellular energy factory. ConA has the higher specificity for tumor cells useful for targeting because of the abnormal glycosylation on tumor cells. When CNT was hitchhiked with and guided by ConA, they could be together internalized to malign cells, and acted like a laser-denotable chemical missile surgically targeting at the tumor cells. We switch on SWIR laser, when the Con_A-CNT conjugated complex has been bonded and internalized to MC of malign cells and already commenced cellular programmed death. Thus, it might appear to casual readers that we have initiated an overkill, chemical drugged autophage followed with physical laser ablation, but what if we can eradicate hepatoma totally if no blue print is left behind inadvertently in case of a partial failure. We conclude that using Con_A-CNT conjugated complex targeting specifically at malign rumor cells is a novel targeted-laser-radiation therapy for rumors in mice.
机译：利用来自杰克束加拿大肉豆蔻伴刀豆球蛋白A（Con_A）的T细胞有丝分裂素称为凝集素蛋白的特性，具有双重活性，细胞毒性和免疫调节作用，我们证明了它对肝癌具有治疗作用。注射ConA可以根除已建立的恶性肿瘤，因为ConA可以诱导肿瘤细胞自噬，细胞程序性死亡并激活效应T细胞。在本文中，结合吸收超过碳纳米管（CNT）的带隙（ε_（bg）=〜1 / CNT直径）和有效的短波近红外（SWIR）（1.2〜1.5微米波长），碰巧对动物皮肤的辐射是半透明的，类似于医院指尖固定式脉搏血氧仪中使用的那种。一旦将ConA-CNT导入肝癌细胞，它就会被结合并内化到细胞能量工厂线粒体（MC）隔室中。由于肿瘤细胞上异常的糖基化，ConA对可用于靶向的肿瘤细胞具有更高的特异性。当CNT被ConA搭接并由ConA引导时，它们可以一起被内化成恶性细胞，并像通过外科手术靶向肿瘤细胞的可激光定位的化学导弹那样起作用。当Con_A-CNT共轭复合物结合并内化到恶性细胞的MC并已经开始细胞程序性死亡时，我们打开SWIR激光器。因此，对于不经意的读者来说，我们已经开始了过度杀伤，化学药物吞噬的巨噬细胞，然后进行了物理激光消融，但是如果在部分失败的情况下无意留下蓝图，那么如果我们可以完全根除肝癌该怎么办。我们得出的结论是，使用Con_A-CNT共轭复合物靶向恶性肿瘤细胞是一种针对小鼠谣言的新型靶向激光辐射疗法。

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