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首页> 外文会议>ICO20: Optical Devices and Instruments >Application of HATR-FTIR Spectroscopy to the Analysis of Nifedipine Tablets
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Application of HATR-FTIR Spectroscopy to the Analysis of Nifedipine Tablets

机译：HATR-FTIR光谱在硝苯地平片分析中的应用

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In recent years, FTIR has been found its wider application in analysis processes of pharmaceutical solids. This is, in part, thanks to the development of powerful multivariate quantitative techniques, such as partial least-squares (PLS) modeling software and the emergence of some new reflectance sampling techniques which allow direct measurement of the IR spectrum of solids in their native states. Horizontal Attenuated Total Reflectance (HATR) is a quite popular sampling technique in recent years. In this work, the feasibility of the Horizontal Attenuated Total Reflectance Infrared Spectroscopy (HATR-FTIR) to the quantitative and quantitative analysis of nimodipine tablets is investigated. Quantitative analysis of nimodipine is carried out by using a classical least-squares for areas procedure. Obtained from validated samples of nimodipine, quantitative results demonstrate clearly the strong potential of HATR-FTIR technique through using quantitative analysis of nimodipine content of pharmaceutical tablets.
机译：近年来，FTIR已被广泛应用于药物固体分析过程。在某种程度上，这要归功于强大的多元定量技术的发展，例如偏最小二乘（PLS）建模软件，以及一些新的反射采样技术的出现，这些技术可以直接测量固体在其原始状态下的红外光谱。水平衰减全反射（HATR）是近年来非常流行的采样技术。在这项工作中，研究了水平衰减全反射红外光谱（HATR-FTIR）对尼莫地平片进行定量和定量分析的可行性。尼莫地平的定量分析是使用经典的最小二乘面积法进行的。从经过验证的尼莫地平样品中获得的定量结果清楚地表明，通过对药物片剂中尼莫地平含量的定量分析，HATR-FTIR技术具有强大的潜力。

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