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首页> 外文会议>IEEE Annual Northeast Bioengineering Conference >Elevated temperature electrospinning of aqueous gelatin solution and crosslinking for tissue engineering applications
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Elevated temperature electrospinning of aqueous gelatin solution and crosslinking for tissue engineering applications

机译：明胶水溶液的高温静电纺丝和用于组织工程应用的交联

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ECM is useful in providing growth and support to the cells as well as engineered tissues. There are various techniques for producing artificial matrix constructs to simulate the ECM. These include wet spinning, phase separation, dry spinning, and electrospinning. Electrospinning has advantages over other techniques as it can produce scaffolds which have a high surface area to volume ratio. Electrospinning is also capable of producing nanofibers from synthetic polymers as well as from natural polymers. Gelatin has been electrospun from several different solvents. In this work we have chosen water as the solvent because of its inherent non-cytotoxicity. When gelatin is dissolved in water it will form a semi-solid gel. Heating the solution will prevent the formation of gel. Electrospun gel fibers will dissolve in water and physiological fluids. To overcome the gelation, an apparatus has been constructed that allows gel solution to be electrospun at elevated temperature. As shown in Figure 1, the apparatus consists of a small insulated enclosure large enough to fit the electrospinning syringe. Heated air is supplied by a heating coil that is connected to a low pressure pump. The heating coil is connected to the Variac by which air can be heated in proportion to the voltage. The Variac is connected to the temperature controller which can turn the Variac on and off relative to a set temperature..
机译：ECM可用于为细胞以及工程组织提供生长和支持。有多种技术可以产生模拟ECM的人工基质构造。这些包括湿法纺丝，相分离，干法纺丝和静电纺丝。电纺丝相对于其他技术具有优势，因为它可以生产具有高表面积与体积比的支架。电纺丝还能够由合成聚合物以及天然聚合物生产纳米纤维。明胶已经从几种不同的溶剂中进行了静电纺丝。在这项工作中，由于水固有的非细胞毒性，我们选择水作为溶剂。当明胶溶于水时，将形成半固体凝胶。加热溶液将防止形成凝胶。电纺凝胶纤维会溶解在水和生理液中。为了克服凝胶化，已经构造了一种设备，该设备允许凝胶溶液在高温下电纺丝。如图1所示，该设备由一个小的绝缘外壳组成，该外壳足够大以适合静电注射器。加热的空气由连接到低压泵的加热线圈提供。加热线圈连接到可变电阻，通过可变电压可以按比例加热空气。 Variac连接到温度控制器，该温度控制器可以相对于设定温度打开和关闭Variac。

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