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首页> 外文会议>IEEE Annual Northeast Bioengineering Conference >Identifying the skull effects to the inertial cavitation threshold of microbubbles in a vessel phantom
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Identifying the skull effects to the inertial cavitation threshold of microbubbles in a vessel phantom

机译：识别颅骨效应对血管模型中微气泡的惯性空化阈值

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bubbles/mL were injected into the channel before sonication (frequency: 1.525 MHz; pulse length: 100 cycles; PRF: 10 Hz; sonication duration: 2 s) through an excised mouse skull. A cylindrically focused hydrophone, confocal with the FUS transducer, acted as a PCD to identify the threshold. A 7.5 MHz linear array with the field-of-view perpendicular to the axial length of the FUS beam was also used to image the occurrence of bubble fragmentation. The broadband spectral response acquired by our PCD and the B-mode images identified the occurrence and location of the inertial cavitation, respectively. Findings indicated that the peak-rarefactional pressure threshold was approximately equal to 0.45 MPa at the presence or the absence of the skull. Mouse skulls did not affect the pressure threshold of inertial cavitation. The broadband response could be captured through the murine skull, so the same PCD setup can be used in future in vivo applications.
机译：通过超声切除小鼠头骨前，将气泡/ mL注入通道中（频率：1.525 MHz；脉冲长度：100个周期； PRF：10 Hz；超声持续时间：2 s）。与FUS传感器共聚焦的圆柱形聚焦水听器充当PCD以识别阈值。视场垂直于FUS光束轴向长度的7.5 MHz线性阵列也用于成像气泡破裂的发生。由我们的PCD和B模式图像获得的宽带光谱响应分别确定了惯性空化的发生和位置。研究结果表明，在有或没有头骨的情况下，峰值反折射压力阈值大约等于0.45 MPa。老鼠的头骨没有影响惯性空化的压力阈值。宽带响应可通过鼠头骨捕获，因此相同的PCD设置可用于将来的体内应用。

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