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首页> 外文会议>IEEE Annual Northeast Bioengineering Conference >Interstitial flow induces MMP-1 expression and SMC migration in 3-D collagen I gels via an ERK1/2-c-Jun pathway and mechanosenation by heparan sulfate proteoglycans and focal adhesions
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Interstitial flow induces MMP-1 expression and SMC migration in 3-D collagen I gels via an ERK1/2-c-Jun pathway and mechanosenation by heparan sulfate proteoglycans and focal adhesions

机译：间隙流通过ERK1 / 2-c-Jun途径诱导3-D胶原I凝胶中MMP-1的表达和SMC迁移以及硫酸乙酰肝素蛋白聚糖和粘着斑的机械化作用

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The migration of vascular smooth muscle cells (SMCs) and fibroblasts into the intima after vascular injury is a central process in vascular lesion formation. The elevation of transmural interstitial flow is also observed after damage to the vascular endothelium. We have previously shown that interstitial flow promotes vascular cell motility in 3-D collagen I gels via upregulation of MMP-1. In this work, we further reveal that interstitial flow-induced MMP-1 expression and cell migration proceeds through the ERK1/2-c-Jun pathway. We also show that heparin sulfate proteoglycans (HSPGs) and focal adhesion kinase (FAK) are sensors and transmitters which convert the interstitial flow stimulus to biomolecular responses and altered cell function (migration). Our findings suggest that interstitial flow shear stress may play an important role in migration of SMCs and fibroblasts during neointima formation and vascular remodeling.
机译：血管损伤后，血管平滑肌细胞（SMCs）和成纤维细胞向内膜的迁移是血管病变形成的主要过程。在损害血管内皮后，还观察到透壁间质流的升高。先前我们已经表明，间质流通过上调MMP-1促进3-D胶原I凝胶中的血管细胞运动。在这项工作中，我们进一步揭示了间质流诱导的MMP-1表达和细胞迁移通过ERK1 / 2-c-Jun途径进行。我们还表明，硫酸肝素蛋白聚糖（HSPG）和粘着斑激酶（FAK）是传感器和传输器，它们将间质流动刺激转换为生物分子反应和改变的细胞功能（迁移）。我们的发现表明，在新内膜形成和血管重塑期间，间质流切应力可能在SMC和成纤维细胞的迁移中起重要作用。

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