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首页> 外文会议>IEEE Annual Northeast Bioengineering Conference >Engineering three-dimensional nervous tissue constructs based on fiber-gel substrates
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Engineering three-dimensional nervous tissue constructs based on fiber-gel substrates

机译：基于纤维-凝胶基质工程化三维神经组织构造

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Three-dimensional (3D) nervous tissue constructs were developed using a compliant gel matrix and a fiber component for promoting contact-guided axon outgrowth. Rat embryonic (E15) dorsal root ganglion expiants (DRGs) were cultured on biodegradable poly-L-lactic acid (PLLA) and wet-spun type I collagen fibers embedded in soft collagen gels. Gel constructs containing fibers induced greater axon outgrowth distances with significantly more directionality along the aligned fibers. Interestingly, wet-spun type I collagen from rat tail tendon displayed a highly aligned outgrowth pattern from DRG axons suggesting potential use for peripheral nerve repair.
机译：使用顺应性凝胶基质和用于促进接触引导的轴突生长的纤维成分开发了三维（3D）神经组织构造。将大鼠胚胎（E15）背根神经节膨大（DRG）培养在可生物降解的聚L-乳酸（PLLA）和湿纺I型胶原纤维上，该纤维包埋在软胶原凝胶中。包含纤维的凝胶构建体诱导更大的轴突向外生长距离，沿着排列的纤维具有明显更多的方向性。有趣的是，来自大鼠尾腱的湿纺I型胶原蛋白表现出DRG轴突的高度排列长出模式，表明可能用于周围神经修复。

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