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Magnetic nanoparticles for magnetomechanical cell destruction and magnetic hyperthermia agents

机译：磁性纳米粒子，用于磁机械细胞破坏和磁热疗剂

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Recently, magnetic nanoparticles are gaining interest for use in magnetic biomedical applications, such as magnetomechanical cell destruction and magnetic hyperthermia. Biofunctionalized NiFe microdiscs, with the application of a low-frequency alternating magnetic field, have been used to demonstrate magnetomechanical cancer-cell destruction by generating an oscillatory motion that transmits a mechanical force to the cell [1]. A magnetization reversal can also occur in magnetic nanoparticles due to a high-frequency alternating magnetic field resulting in the production of thermal energy, which is expressed by the specific absorption rate (SAR) [2]. The heating ability of magnetic nanoparticles shows great potential for a non-invasive and powerful therapy technique for biomedical applications, such as magnetic hyperthermia. By focusing the magnetic nanoparticles at the tumor site, the temperature at the targeted region can be raised to 42-46 °C, which will greatly lower the viability of cancer cells. The advantage of these methods over the conventional cancer therapy is the localization of treatment of the cancer tumor, which minimizes the detrimental side effects experienced by the patient.
机译：近来，磁性纳米颗粒在诸如磁性机械细胞破坏和磁性热疗之类的磁性生物医学应用中越来越受关注。经过低频交变磁场作用的生物功能化NiFe微盘已被用于通过产生将机械力传递至细胞的振荡运动来证明磁机械癌细胞的破坏[1]。由于高频交变磁场的作用，磁性纳米颗粒中也会发生磁化反转，从而产生热能，热能由比吸收率（SAR）表示[2]。磁性纳米颗粒的加热能力显示了用于生物医学应用（例如磁热疗）的非侵入性且功能强大的治疗技术的巨大潜力。通过将磁性纳米粒子聚焦在肿瘤部位，目标区域的温度可以升高到42-46°C，这将大大降低癌细胞的生存能力。这些方法相对于常规癌症疗法的优势在于癌症肿瘤的治疗定位，这使患者所经历的有害副作用最小化。

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