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首页> 外文会议>IMAPS 2008 - 41st international symposium on microelectronics: bringing together the entire microelectronics supply chain >LTCC Based Microfluidic Structures for the Controlled Synthesis of Antioxidant Polymers
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LTCC Based Microfluidic Structures for the Controlled Synthesis of Antioxidant Polymers

机译：基于LTCC的微流控结构用于可控合成抗氧化剂聚合物

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摘要

Low Temperature Co-fired Ceramic (LTCC) based microfluidic structures have been designed and applied to the controlled polymerization of a new type of biomaterial, antioxidant polymers. Oxidation mediated tissue injury can occur due to the local accumulation of degradable byproducts of polymeric biomaterials. In order to avoid these effects, polymers composed of synthetic antioxidant Trolox have been synthesized. Trolox, released as a degradation product, can theoretically attenuate or prevent this material induced oxidative stress mechanism and site inflammation by providing slow antioxidant release. Despite success with the synthesis of oligomers of Trolox, the synthesis of longer chain polymers has represented a significant technological challenge.rnThe current paper reviews the fabrication and design of LTCC based microfluidic reactor modules and flow conditions required to provide improved control the Trolox polymerization process. Microfluidic channels have been fabricated using commercial LTCC materials and traditional LTCC processing technologies. Patterning of channels has been conducted using CNC micromilling and laser ablation tools. The application of computer assisted LTCC fabrication technologies has allowed a large degree of design flexibility and the rapid deployment of reactor design revisions. The proposed reactor utilizes three streams of co-laminar flow to allow for the controlled introduction of monomer and condensation pairs into the reaction stream. Reactor design and flow conditions have been refined to provide an improved method for control of the degree of polymerization and polydispersity in the product stream. This work demonstrates the inherent advantages of microfluidic based synthesis techniques for the production of highly customized polymeric materials.
机译：已经设计了基于低温共烧陶瓷（LTCC）的微流体结构，并将其应用于新型生物材料抗氧化剂聚合物的受控聚合。氧化介导的组织损伤可能由于聚合生物材料可降解副产物的局部积累而发生。为了避免这些影响，已经合成了由合成抗氧化剂Trolox组成的聚合物。 Trolox作为降解产物释放，通过提供缓慢的抗氧化剂释放，理论上可以减弱或防止该物质诱导的氧化应激机制和部位发炎。尽管Trolox的低聚物合成取得成功，但长链聚合物的合成仍代表着重大的技术挑战。微流体通道已经使用商用LTCC材料和传统LTCC加工技术制成。通道的图案化已使用CNC微铣削和激光烧蚀工具进行。计算机辅助LTCC制造技术的应用使设计具有很大的灵活性，并迅速部署了反应堆设计修订版。所提出的反应器利用三层共层流，以允许将单体和缩合对引入反应流中。反应器的设计和流动条件已得到改进，以提供一种改进的方法来控制产物流中的聚合度和多分散性。这项工作证明了基于微流体的合成技术在生产高度定制的聚合物材料方面的固有优势。

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