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Automated characterization of amoeboid motility

机译:变形肌运动的自动表征

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Cells use a variety of methods to migrate. One of these, referred to as amoeboid motion, involves alternating cycles of morphological expansion and retraction. Employed by numerous mammalian cell lines including neutrophils and lymphocytes, it is also seen in the metastatic migration of some tumor cells. Amoeboid motility is best understood in the social amoeba Dictyostelium discoideum. It is a complex cellular process driven by highly-organized cytoskeletal dynamics containing numerous molecular species and regulated by an intricate signaling network. An important aspect of studying is to understand how the roles played by these molecules and signaling pathways are integrated. And a widely used approach is to characterize phenotype-specific morphological dynamics among various types of cells.
机译:细胞使用多种方法进行迁移。其中之一被称为变形虫运动,涉及形态学扩张和收缩的交替循环。它被包括中性粒细胞和淋巴细胞在内的许多哺乳动物细胞系所利用,在某些肿瘤细胞的转移性迁移中也可以看到它。变形虫的运动能力最好在社交变形虫盘基网柄菌Discoidesteo Discumideum中得到理解。这是一个复杂的细胞过程,由高度组织化的细胞骨架动力学驱动,包含许多分子种类,并受复杂的信号网络调节。研究的重要方面是了解这些分子和信号通路所起的作用是如何整合的。一种广泛使用的方法是表征各种类型细胞之间的表型特异性形态动力学。

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