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Search for the algorithm of genes distribution during the process of microbial evolution

机译：在微生物进化过程中寻找基因分布的算法

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Previous two and three dimensional graph analysis of eco-physiological data of Archaea demonstrated specific geometry for distribution of major Prokaryotic groups in a hyperboloid function. The function of a two-sheet hyperboloid covered all known biological groups, and therefore, could be applied for the entire evolution of life on Earth. The vector of evolution was indicated from the point of hyper temperature, extreme acidity and low salinity to the point of low temperature and increased alkalinity and salinity. According to this vector, the following groups were chosen for the gene screening analysis. In the vector "High-Temperature → Low-Temperature" within extreme acidic pH (0-3), it is: 1) the hyperthermophilic Crenarchaeota - order Sulfolobales, 2) moderately thermophilic Euryarchaeota - Class Thermoplasmata, and 3) mesophilic acidophiles- genus Thiobacillus and others. In the vector "Low pH → High pH" the following groups were selected in three temperature ranges: a) Hyperthermophilic Archaea and Eubacteria, b) moderately thermophilic - representatives of the genera Anaerobacter and Anoxybacillus, and c) mesophilic haloalkaliphiles (Eubacteria and Archaea). The genes associated with acidophily (H~+ pump), chemolitho-autotrophy (proteins of biochemichal cycles), polymerases, and histones were proposed for the first vector, and for the second vector the genes associated with halo-alkaliphily (Na~+ pumps), enzymes of organotrophic metabolisms (sugar- and proteo-lytics), and others were indicated for the screening. Here, an introduction to the phylogenetic constant (p_η) is presented and discussed. This universal characteristic is calculated for two principally different life forms -Prokaryotes and Eukaryotes; Existence of the second type of living forms is impossible without the first one. The number of chromosomes in Prokaryotic organisms is limited to one (with very rare exceptions, to two), while in Eukaryotic organisms this number is larger. Currently, accumulation of data for genome sequences is in progress: about 3,500 draft sequences of genomes are available (of the total 12,000 species Bacteria and Archaea). The possibility of confirmation of the previously proposed mathematical model with an approach for genes screening in determined key groups of microorganisms in genomes databases is outlined and discussed in this article.
机译：先前的古细菌生态生理数据的二维和三维图形分析显示了双曲面功能中主要原核生物基团分布的特定几何形状。两页双曲面的功能涵盖了所有已知的生物组，因此可以应用于地球生命的整个进化。从高温，极端酸度和低盐度的角度到低温和增加碱度和盐度的角度显示了演化的载体。根据该载体，选择以下组进行基因筛选分析。在极端酸性pH（0-3）内的“高温→低温”向量中，它是：1）超嗜热Crenarchaeota-嗜盐菌，2）中度嗜热Euryarchaeota-嗜热菌属，3）中温嗜酸菌属硫杆菌属和其他。在“低pH→高pH”载体中，在三个温度范围内选择了以下几组：a）嗜热古细菌和真细菌，b）中度嗜热-厌氧杆菌和无氧杆菌属的代表，以及c）嗜中性嗜盐嗜碱菌（真细菌和古细菌） 。为第一个载体提出了与嗜酸性（H〜+泵），化学自养（生物化学循环蛋白），聚合酶和组蛋白相关的基因，对于第二个载体，提出了与卤代碱度相关的基因（Na〜+泵） ），有机营养代谢酶（糖和蛋白水解酶）以及其他用于筛选的酶。在这里，介绍并讨论了系统发育常数（p_η）。这个普遍特征是针对两种主要不同的生命形式（原核生物和真核生物）计算的。没有第一种，就不可能存在第二种生活形式。在原核生物中，染色体的数目被限制为一个（非常罕见的例外是两个），而在真核生物中，该数目更大。目前，有关基因组序列的数据的积累正在进行中：大约有3500个基因组草图序列可用（总共12,000个细菌和古细菌）。本文概述并讨论了使用在基因组数据库中确定的关键微生物组中进行基因筛选的方法来确认先前提出的数学模型的可能性。

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