首页> 外文会议>Integrated continuous biomanufacturing II >PAT concepts for chromatography: Real-time monitoring, real-time control, and cause of error diagnostics

【24h】

PAT concepts for chromatography: Real-time monitoring, real-time control, and cause of error diagnostics

机译：色谱法的PAT概念：实时监控，实时控制和错误诊断原因

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

In the recent years, the growing competition in the biopharmaceutical industry due to biosimilars combined with market fluctuations and increasing product pipelines have given rise to the evaluation of continuous processing. Advantages include smaller e□uipment that may be disposable, an overall process intensification as well as steady-state operation. As variability should be managed by the continuous process itself to insure a consistent product □uality, the development of advanced Process Analytical Technology (PAT) concepts is one crucial aspect for the implementation of continuous processing.

机译：近年来，由于生物仿制药，市场波动以及不断增加的产品线，生物制药行业的竞争日趋激烈，因此对连续加工进行了评估。优点包括较小的设备（可以一次性使用），整个过程的增强以及稳态操作。由于应由连续过程本身来管理可变性以确保产品质量的一致性，因此先进过程分析技术（PAT）概念的开发是实现连续过程的关键方面。

著录项

来源
《Integrated continuous biomanufacturing II》|2015年|221-222|共2页
会议地点 Berkeley CA(US)
作者
Nina Brestrich; Tobias Hahn; Adrian Sanden; Till Briskot; Jurgen HUbbuch;
展开▼
作者单位

Karlsruhe Institute of Technology;

Karlsruhe Institute of Technology;

Karlsruhe Institute of Technology;

Karlsruhe Institute of Technology;

Karlsruhe Institute of Technology;

展开▼
会议组织
原文格式 PDF
正文语种 eng
中图分类
关键词
Process analytical technology; Real-time monitoring of co-eluting proteins; Real-time pooling; Cause of error-diagnostics; PLS and mechanistic modelling;

机译：工艺分析技术；实时监测共洗脱蛋白；实时池化；错误诊断原因； PLS和机械建模;

相似文献

外文文献
中文文献
专利

1. Controlling real-time efficiency - Choosing the right process technology can help food and beverage manufacturers reduce on-shelf product errors and achieve real-time efficiency [J] . Annie Dang PACE: Process & Control Engineering . 2011,第11期

机译：控制实时效率-选择正确的工艺技术可以帮助食品和饮料制造商减少货架上的产品错误并实现实时效率
2. Controlling real-time efficiency - Choosing the right process technology can help food and beverage manufacturers reduce on-shelf product errors and achieve real-time efficiency [J] . Annie Dang PACE: Process & Control Engineering . 2011,第11期

机译：控制实时效率 - 选择合适的过程技术可以帮助食品和饮料制造商减少货架产品误差并实现实时效率
3. Nuclear Power Plant Cooling System Performance Improvement through Real-Time Monitoring,Diagnostics and Control [J] . Andrew Kern, Peter Ten Eyck, George Peabody PowerPlant Chemistry: The Journal of All Power Plant Chemistry Areas . 2008,第3期

机译：通过实时监控，诊断和控制提高核电厂冷却系统性能
4. NUCLEAR POWER PLANT COOLING SYSTEM PERFORMANCE IMPROVEMENT THROUGH REAL-TIME MONITORING, DIAGNOSTICS AND CONTROL [C] . Annual International Water Conference . 2007

机译：核电站通过实时监控，诊断和控制进行核电站的性能改善
5. Real-time intelligent monitoring and diagnostic system for a CNC turret lathe in a production environment using multi-sensing and neural network. [D] . Ukpong, Anietie Udo. 1998

机译：使用多传感和神经网络的生产环境中的数控转塔车床实时智能监控和诊断系统。
6. Online monitoring and error detection of real-time tumor displacement prediction accuracy using control limits on respiratory surrogate statistics [O] . Kathleen Malinowski, Thomas J. McAvoy, Rohini George, -1

机译：使用呼吸替代物统计的控制极限对实时肿瘤位移预测准确性进行在线监测和错误检测
7. P1246Age-, body size-, and sex-specific reference values for tricuspid valve apparatus parameters by real-time three-dimensional transthoracic echocardiographyP1247Surgical therapy in infective endocarditis: predisposing and prognostic factorsP1248Evalutation of MV annulus geometry modifications before and after mitraclip implantation with 3D transesophageal echocardiographyP1249Prognostic echocardiographic parameters for successful transcatheter edge-to-edge mitral valve repairP1250Influence of body surface area in diagnosis and outcome patient-prosthesis mismatch after TAVI. Is it necessary to adjust for ideal body weight?P1251Outcome of paradoxical low-flow low-gradient severe AS following TAVI: paradoxical VS parallel to outcome of high gradient ASP1252Prognostic role of cardiac calcifications in subjects without overt significant heart disease and previous cardiovascular events: is there an additive value over cardiovascular risk factors scores?P1253Aging degeneration of mitral valve without leaflet prolapse or tethering as a cause of severe mitral regurgitationP1254Cardiovascular risk assessment should be performed in patients with incidental aortic sclerosisP1255Cardiac valve calcification score: simple 2D echocardiographic tool for cardiovascular risk stratification in patients with chronic renal failureP1256Diastolic mitral regurgitation following transcatheter aortic valve replacement: prevalence, predictors and impact on outcomesP1257Timing of myocardial shortening determines left ventricular regional remodelling in hearts with conduction delaysP1258Myocardial stiffness assessment using shear wave imaging in healthy children and hypertrophic cardiomyopathyP1259Assessment of right ventricular response to exercise using vector velocity imaging in hypertrophic cardiomyopathyP1260Diagnostic value of cardiac biomarkers (high sensitive troponin T and N-terminal pro-brain natriuretic peptide) in patients with infiltrative cardiomyopathiesP1261Right ventricular global longitudinal strain differentiates between adolescent patients with definite, borderline and possible ARVC and controlsP1262 echogrqphic predictif factors of atrial arrhythmias in patients with arrhythmogenic right ventricular dysplasiaP1263Importance of combined left atrial size and estimated pulmonary pressure for clinical outcome in patients presenting with heart failure with preserved ejection fractionP1264Chronotropic response in mitochondrial (ANT1) cardiomyopathyP1265 The effect of cardiovascular risk factors and cancer type in anthracycline's cardiotoxicityP1266Revisiting the echocardiographic features of acute myocarditisP1267Altered circulation in fetuses of diabetic mothers: a fetal computational model analysisP1268Increased epicardial adipose tissue is related to stress-induced cardiomyopathyP1269Contrast enhanced ultrasound of kidney perfusion in patients with renal artery stenosis: diagnostic and prognostic applications. [O] . F. Ancona, R. Ilhao Moreira, V. Lavanco, 2016

机译：P1246age-，身体大小和性别特异性参考Tricuspid阀装置参数通过实时三维经线性超声心动图124772777777747774747478EVALIGUTALMEXP1249预期植入前后MV环形植入前后MV环空性修饰。超声心动图参数用于成功的经截管边缘到边缘二尖瓣修复P1250中的体表面积诊断和结果患者假体在Tavi后的不匹配。是否有必要调整理想的体重？P1251矛盾的低流量低梯度严重，如Tavi：矛盾的VS平行于高梯度ASP1252的结果，在没有明显显着的心脏病和以前心血管事件的情况下心脏钙化的促傲作用患有心血管危险因素的添加剂值分数？没有传单脱垂的二尖瓣退化或作为严重二尖瓣血管血管血管病风险评估的患者进行脱垂或系绳，应当在偶然主动脉源肺源P1255Cariac阀钙化评分患者中进行：用于心血管风险分层的简单2D超声心动图工具在慢性肾功能衰竭的患者中，经沟管主动脉瓣膜置换术后：流行率，预测因子和对Otcomasp1257的影响，心肌缩短决定了导通延迟的心中的剩余心室区域重新耦合258MYCIARIAL僵硬评估使用剪切波成像在健康儿童和肥厚性心肌脑病中的舒缓性心脏响应，在渗透心肌肌瘤患者中使用载体速度成像的培养速度成像（高敏感的肌钙蛋白T和N-末端脑Natrietic肽）渗透心肌病，患者心室全局纵向菌株在患有心律失常右心室发育不良患者的心理心律失常患者中的青少年患者与Controlsp1262 echogrqphic预测因子的分歧，患者心血性右心室发育不良患者患者患者患者患者患者患者患者患者患者线粒体（ANT1）心肌病患者的喷射FRACTIONP1264系列响应1265心血管危险因素和癌症类型在蒽丙烯的心肌毒性皮1126660中的影响访问患有糖尿病母亲胎儿胎儿急性心肌炎的超声心动图，患者患者：胎儿计算模型分析P1268增加外膜脂肪组织与肾动脉狭窄患者肾脏灌注的应激诱导的心肌病，增强超声波：诊断和预后应用。

PAT concepts for chromatography: Real-time monitoring, real-time control, and cause of error diagnostics

摘要

著录项

相似文献

相关主题

期刊订阅