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首页> 外文会议>International symposium on controlled release of bioactive materials;Consumer diversified products conference >MECHANISMS OF IMMUNOGLOBULIN G (IgG) TRANSPORT ACROSS PRIMARY CULTURED RAT ALVEOLAR EPITHELIAL CELL MONOLAYERS
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MECHANISMS OF IMMUNOGLOBULIN G (IgG) TRANSPORT ACROSS PRIMARY CULTURED RAT ALVEOLAR EPITHELIAL CELL MONOLAYERS

机译：免疫球蛋白G（IgG）跨原代培养大鼠肺泡上皮细胞单层膜运输的机制

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We studied mechanisms of IgG transport across primary cultured rat alveolar epithelial cell monolayers. IgG transport was rapid and saturable, yielding net absorption. Lowering temperature to 4℃ from 35℃ led to ～75% decrease in IgG transport in the apical-to-basolateral (ab) direction, while IgG transport in the opposite (ba) direction completely stopped. Excess unlabeled Fc (but not Fab, F(ab')~2, or IgY) competed significantly with labeled IgG transport in either direction. Dexamethasone treatment led to reduction of absorptive IgG fluxes after 48 hr. These data suggest that IgG transport takes place via Fc-recognizing receptors expressed in alveolar epithelial cells and that IgG absorption across alveolar epithelium is regulable by glucocorticoids.
机译：我们研究了跨主要培养的大鼠肺泡上皮细胞单层的IgG转运的机制。 IgG转运迅速且可饱和，产生净吸收。将温度从35℃降低到4℃，导致IgG在根尖至基底外侧（ab）方向的转运降低〜75％，而IgG在相反（ba）方向的转运完全停止。过量的未标记Fc（但不是Fab，F（ab'）〜2或IgY）在任一方向上均与标记的IgG转运显着竞争。地塞米松治疗导致48小时后吸收性IgG流量减少。这些数据表明，IgG的转运是通过在肺泡上皮细胞中表达的Fc受体进行的，并且糖皮质激素可调节IgG跨肺泡上皮的吸收。

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