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首页> 外文会议>International symposium on halogenated persistent organic pollutants >TISSUE DISTRIBUTION OF POLYBROMINATED DIPHENYL ETHERS AND METABOLITES IN RAINBOW TROUT (ONCORHYNCHUS MYKISS) AFTER EXPOSURE TO DECABROMODIPHENYL ETHER (BDE209)
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TISSUE DISTRIBUTION OF POLYBROMINATED DIPHENYL ETHERS AND METABOLITES IN RAINBOW TROUT (ONCORHYNCHUS MYKISS) AFTER EXPOSURE TO DECABROMODIPHENYL ETHER (BDE209)

机译：十溴二苯醚（BDE209）暴露后，虹鳟中的多溴二苯醚和代谢产物的组织分布

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Tissue-specific distribution of BDE209 metabolites, including debrominated polybrominated diphenyl ethers and methoxylated brominated diphenyl ethers (MeO-BDEs) were analyzed in muscle, liver and blood of rainbow trout. Rainbow trout was exposed to BDE209 via a single intraperitoneal injection (about 500ng/g wet weight) for 28 days. The results showed that the BDE209 metabolite distribution varied in different fish tissues. As for BDE209 itself, the relatively higher concentrations were detected in muscles, from 7841.15 ng/g dry weight on day 1 to 2748.56 ng/g dry weight on day 28. BDE209 concentrations in livers were much lower than in muscles, day 1 (mean=227.99ng/g wet weight) and day 28 (mean= 236.39ng/g wet weight), respectively. Nevertheless, BDE209 was not detected in blood at both sampling times. There existed obvious differences of BDE and MeO-BDE distribution in different fish tissues. As for the debrominated BDE metabolites, the main debrominated BDE metabolites in muscle were tetra-, penta- and nona-BDEs. While in liver, the debrominated metabolites composed of mono-, di-, hepta-, octa- and nona-BDEs. However in blood, only mono-, di-, and tetra-BDEs were observed during the exposure. Regarding the MeO-BDE metabolites, totally seven MeO-BDE metabolites were observed among different fish tissues. Individual MeO-BDE congeners in different tissues all presented an increase trend during the whole exposure period, with the most detection rate occurring in blood. In summary, BDE209 preferred to remain in muscle of rainbow trout, furthermore, BDE209 and its higher brominated diphenyl ether metabolites were more stable in muscle than in liver and blood of rainbow trout. However, BDE209 tended to degrade quickly into lower BDEs and MeO-BDEs in blood of rainbow trout.
机译：在虹鳟鱼的肌肉，肝脏和血液中分析了BDE209代谢产物的组织特异性分布，包括脱溴的多溴二苯醚和甲氧基化的溴化二苯醚（MeO-BDEs）。通过一次腹膜内注射（约500ng / g湿重）将虹鳟暴露于BDE209中28天。结果表明，BDE209代谢产物在不同鱼类组织中的分布不同。至于BDE209本身，在肌肉中检测到相对较高的浓度，从第1天的7841.15 ng / g干重到第28天的2748.56 ng / g干重。肝脏中BDE209的浓度远低于肌肉，第1天（平均值） = 227.99ng / g湿重）和第28天（平均= 236.39ng / g湿重）。但是，在两个采样时间均未在血液中检测到BDE209。不同鱼类组织中BDE和MeO-BDE的分布存在明显差异。至于脱溴的BDE代谢物，肌肉中主要的脱溴的BDE代谢物是四溴，五溴和九溴二苯醚。在肝脏中时，脱溴代谢物由单，二，七，八和九溴二苯醚组成。但是，在血液中，在暴露过程中仅观察到单，二和四溴联苯醚。关于MeO-BDE代谢物，在不同鱼类组织中共观察到7种MeO-BDE代谢物。在整个暴露期间，不同组织中的各个MeO-BDE同系物均呈上升趋势，其中血液中的检出率最高。总之，BDE209倾向于保留在虹鳟鱼的肌肉中，此外，BDE209及其更高溴化的二苯醚代谢物在肌肉中比在虹鳟鱼的肝脏和血液中更稳定。但是，BDE209在虹鳟鱼血液中倾向于迅速降解为较低的BDE和MeO-BDE。

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