首页> 外文会议>International Astronautical Congress(IAC2006); 20061002-06; Valencia(ES) >THE EFFECTS OF A NOVEL ‘FLUID-LOADING’ STRATEGY COMBINING CREATINE AND GLYCEROL ON FLUID RETENTION AND DISTRIBUTION IN HUMANS
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THE EFFECTS OF A NOVEL ‘FLUID-LOADING’ STRATEGY COMBINING CREATINE AND GLYCEROL ON FLUID RETENTION AND DISTRIBUTION IN HUMANS

机译:新型的“流体加载”策略将芥子油和甘油结合起来对人类的流体滞留和分布的影响

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摘要

The effects of three "fluid-loading" strategies combining creatine (Cr) and glycerol (Gly) on fluid retention and distribution were examined. Three 7-day Cr and Gly loading protocols (LP) were examined: LP1 - 10 g Cr and 75 g of glucose in 1 litre (L) of water (x 2 daily) and a bolus of 1 g Gly·kg~(-1) 2.5 hours prior to testing (n = 6); LP2 - 10 g Cr, 1 g Gly·kg~1 and 75 g of glucose in 1 L of water (x 2 daily) and final supplement consumed 3 hours prior to testing (n = 6); LP3 - as LP2 but final supplement consumed 5 hours prior to testing (n = 23). Only body mass increased (mean ± s.d.) by 1.59 ± 0.21 kg (P < 0.01) post-LPl and by 1.20 ± 0.37 kg (P < 0.01) post-LP2. Post-LP3, body mass increased by 0.97 ± 0.28 kg (P < 0.01) with significant increases in total body water (0.87 ± 0.21 L; P < 0.01), intra-cellular and extra-cellular water and plasma volume. Combining Cr and Gly is potentially a clinically useful "fluid-loading" strategy which merits further evaluation for application in spaceflight.
机译:检查了结合肌酸(Cr)和甘油(Gly)的三种“流体加载”策略对流体保留和分布的影响。检查了三个7天的Cr和Gly加载方案(LP):LP1-10 g Cr和75 g葡萄糖在1升(L)水中(每天x 2)和1 g Gly·kg〜(- 1)测试前2.5小时(n = 6); LP2-在1 L水(每天x 2)中含10 g Cr,1 g Gly·kg〜1和75 g葡萄糖(每天x 2),并在测试前3小时消耗了最终补充剂(n = 6); LP3-与LP2一样,但最终补品在测试前5小时就已消耗掉(n = 23)。在LP1后仅体重增加(平均值±s.d。)1.59±0.21kg(P <0.01),在LP2后仅增加1.20±0.37kg(P <0.01)。 LP3后,体重增加了0.97±0.28 kg(P <0.01),体内总水(0.87±0.21 L; P <0.01),细胞内和细胞外水以及血浆体积显着增加。结合使用Cr和Gly可能是一种临床上有用的“流体加载”策略,值得进一步评估其在航天中的应用。

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