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首页> 外文会议>International conference on advancements of medicine and health care through technology >A Method to Increase the Pulsatility in Hemodynamic Variables in an LVAD Supported Human Circulation System
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A Method to Increase the Pulsatility in Hemodynamic Variables in an LVAD Supported Human Circulation System

机译：在LVAD支持的人体循环系统中增加血流动力学变量搏动性的方法

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Left Ventricular Assist Devices (LVADs) gener ally operate at a constant speed in the human body. This causes a decrease in the pulsatility of hemodynamic variables. To increase the pulsatility a stepwise change was applied to the LVAD operating speed over a cardiac cycle. To do this, a nu merical cardiovascular system model and a pump model were used. The model was developed by considering the static char acteristics of the MicroMed DeBakey LVAD. First, the simula tions were performed at constant operating speeds, 8500 rpm, 9500 rpm and 10500 rpm. Pulsatility indexes were calculated for left ventricular (LV) pressure, aortic pressure, LV volume and LVAD flow. Cardiac output (CO) was calculated at con stant operating speed and these values used for comparing the pulsatility indexes with stepwise and constant operating speeds. The LVAD was operated at two different constant speeds in the stepwise operating speed simulations. Low and high operating speeds were adjusted so as to obtain the same cardiac output values with the constant operating speed simu lations. The operating speeds in the simulations were 7800-11250 rpm, 9300-11250 rpm and 10300-11250 rpm. The same cardiac output values were obtained with an increase in the pulsatility of the hemodynamic variables without significant changes in their shapes except the LVAD flow. The obtained results show that it is possible to obtain more physiological results by applying a stepwise change to LVAD operating speed over a cardiac cycle.
机译：左心室辅助设备（LVAD）通常在人体中以恒定速度运行。这导致血液动力学变量的搏动性降低。为了增加搏动性，在心动周期中对LVAD操作速度进行了逐步更改。为此，使用了数字心血管系统模型和泵模型。该模型是通过考虑MicroMed DeBakey LVAD的静态特性而开发的。首先，以恒定的运行速度（8500 rpm，9500 rpm和10500 rpm）进行仿真。计算左心室（LV）压力，主动脉压，LV体积和LVAD流量的搏动指数。在恒定的工作速度下计算心输出量（CO），并将这些值用于将脉动指数与逐步和恒定的工作速度进行比较。 LVAD在逐步运行速度模拟中以两种不同的恒定速度运行。调整低和高操作速度，以便在恒定的操作速度模拟下获得相同的心输出量。模拟中的运行速度为7800-11250 rpm，9300-11250 rpm和10300-11250 rpm。血流动力学变量的搏动性增加时，可获得相同的心输出量，除了LVAD流量外，其形状没有明显变化。获得的结果表明，通过在心动周期上逐步改变LVAD的工作速度，可以获得更多的生理结果。

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