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Algebraic Systems Biology: Theses and Hypotheses

机译:代数系统生物学:论点和假设

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摘要

What is systems biology? What can biologists gain from an attempt to algebraize the questions in systems biology? Starting with plausible biological theses, can one algebraically model them and then manipulate them to suggest meaningful hypotheses? Using these hypotheses, can one measure and mine suitable experimental data to validate or refute these hypotheses? Through these intertwined processes of measuring, mining, modeling and manipulating biological systems, can one generate the set of theses and hypotheses upon which systems biology will be founded? This review provides one algorithmic-algebraist's somewhat idiosyncratic response to these and other related questions, but also aims to persuade young algebraists to examine the possible role they and algebra can play to enrich this subject.
机译:什么是系统生物学?尝试将系统生物学中的问题代数化,生物学家会得到什么?从似乎合理的生物学命题开始,可以代数建模它们,然后操纵它们以提出有意义的假设吗?使用这些假设,可以衡量和挖掘合适的实验数据来验证或驳斥这些假设吗?通过这些对生物系统进行测量,挖掘,建模和操纵的相互交织的过程,是否可以得出一系列的论据和假设,以这些生物学为基础?这篇综述提供了一个算法代数学家对这些问题和其他相关问题的某种特质反应,而且还旨在说服年轻的代数学家研究他们和代数在丰富这一主题方面可能发挥的作用。

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