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首页> 外文会议>International Conference of Computational Methods in Sciences and Engineering 2007(ICCMSE 2007); 20070925-30; Corfu(GR) >Two-Step Fuzzy Multicriteria Ranking of Whole Cells Immobilization Methods for Biosensor/Biocatalyst Selection/Synthesis
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Two-Step Fuzzy Multicriteria Ranking of Whole Cells Immobilization Methods for Biosensor/Biocatalyst Selection/Synthesis

机译：生物传感器/生物催化剂选择/合成全细胞固定化方法的两步模糊多标准排序

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摘要

This work deals with the design/development of a methodological framework, under the form of an algorithmic procedure, including 23 activity stages and 7 decision nodes, for fuzzy multicriteria ranking of whole cells immobilization methods (WIMs) for biosensor/bjocatalyst selection/synthesis. An implementation of this procedure, is presented with the following alternatives/criteria, extracted by experts' opinion through a modified Delphi method (in a fuzzy version to count for uncertainty) in such a way that can be easily utilized in special cases of R&D or commercial interest. First-step alternatives: adsorption, cell to cell crosslinking, covalent bonding, entrapment, microencapsulation; Second-step alternatives: gelation, ionotropic gelation, polycondensation, polymerization, precipitation of polymers. Criteria (common to both steps): total cost, mean relative activity, mean absolute activity, mean efficiency, stability/reliability. Detailed monoparametric sensitivity analysis, as regards the impact of each criterion's weight on the suggested/preferred alternative, is performed, and incomparabilities within certain pairs of alternatives are investigated.
机译：这项工作以算法程序的形式，包括23个活动阶段和7个决策节点的方法，针对生物传感器/活性炭选择/合成的全细胞固定方法（WIM）的模糊多标准排序，处理方法框架的设计/开发。提出了以下程序/标准的此程序的实施方案，这些方案/标准是专家意见通过改进的Delphi方法（模糊版本以计算不确定性）提取的，以便可以在特殊的R＆D或商业利益。第一步替代方案：吸附，细胞间交联，共价键合，包封，微囊化；第二步替代方法：凝胶化，离子化凝胶化，缩聚，聚合，聚合物沉淀。准则（两个步骤共同使用）：总成本，平均相对活动，平均绝对活动，平均效率，稳定性/可靠性。关于每个标准权重对建议的/首选的替代方案的影响，进行了详细的单参数敏感性分析，并研究了某些替代方案对中的不相容性。

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