Evolutionary Perspectives on Protein Thermodynamics

机译：蛋白质热力学的进化观点

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While modern evolutionary theory has emphasized the role of neutral evolution, protein biochemistry and biophysics has interpreted the properties of proteins as largely resulting from adaptive evolution. We demonstrate that a number of these properties can be seen as emerging from neutral evolution acting on sequence entropy, that is, the fact that larger numbers of viable sequences have these properties. In this paper, we use a computational model of populations of evolving lattice proteins to describe how the observed marginal stability of proteins as well as their robustness to mutations can result from neutral evolution.

机译：尽管现代进化论强调了中性进化的作用，但蛋白质生物化学和生物物理学已将蛋白质的特性解释为很大程度上由适应性进化产生。我们证明了许多这些特性可以看作是由作用于序列熵的中性进化形成的，也就是说，大量的可行序列具有这些特性。在本文中，我们使用进化的点阵蛋白质种群的计算模型来描述观察到的蛋白质的边际稳定性及其对突变的稳健性如何由中性进化产生。

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《International Conference on Computational Science pt.4; 20040606-20040609; Krakow; PL》|2004年|P.718-727|共10页
会议地点 Krakow(PL);Krakow(PL)
作者
Richard A. Goldstein;
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作者单位

Division of Mathematical Biology, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK;

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原文格式 PDF
正文语种 eng
中图分类理论、方法;
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1. Thermodynamics and kinetics of protein folding: an evolutionary perspective. [J] . Demetrius L Journal of Theoretical Biology . 2002,第3期

机译：蛋白质折叠的热力学和动力学：进化的观点。
2. Evolutionary stabilization of the gene-3-protein of phage fd reveals the principles that govern the thermodynamic stability of two-domain proteins. [J] . Martin A, Schmid FX Journal of Molecular Biology . 2003,第4期

机译：噬菌体fd基因3蛋白的进化稳定性揭示了控制两个域蛋白热力学稳定性的原理。
3. Thermodynamic and Evolutionary Coupling between the Native and Amyloid State of Globular Proteins [J] . Tobias Langenberg, Rodrigo Gallardo, Rob van der Kant, Cell Reports . 2020,第2期

机译：球状蛋白的天然和淀粉样蛋白状态之间的热力学和进化耦合
4. Evolutionary Perspectives on Protein Thermodynamics [C] . Richard A. Goldstein, Lecture Notes in Computer Science 3039 International Conference on Computational Science . 2004

机译：蛋白质热力学的进化视角
5. Protein domain superfamilies: An evolutionary perspective towards a non-redundant classification of protein domains. [D] . Cherukuri, Praveen Frazer. 2007

机译：蛋白质结构域超家族：对蛋白质结构域的非冗余分类的进化观点。
6. Beyond Thermodynamic Constraints: Evolutionary Sampling Generates Realistic Protein Sequence Variation [O] . Qian Jiang, Ashley I. Teufel, Eleisha L. Jackson, 2018

机译：超越热力学约束：进化采样产生逼真的蛋白质序列变异
7. Evolutionary Perspectives on Protein Thermodynamics [O] . Richard A. Goldstein 2004

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8. Functional characteristics of the calcium modulated proteins seen from an evolutionary perspective [R] . Kretsinger, R. H., Nakayama, S., Moncrief, N. D. 1991

机译：从进化的角度看钙调节蛋白的功能特征

Evolutionary Perspectives on Protein Thermodynamics

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