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首页> 外文会议>International Conference on Electrical, Electronics, and Optimization Techniques >Composition, formulation and in-vitro evaluation studies of cefixime microspheres
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Composition, formulation and in-vitro evaluation studies of cefixime microspheres

机译：头孢克肟微球的组成，制剂和体外评估研究

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The aim of the study was to formulate and evaluate sustain release microspheres of Cefixime by orifice ionic gelation method. Different formulations were prepared using different ratios of drug and sodium alginate as polymer alone and in combination with co-polymers like, HPMC K15M using calcium chloride acts as cross linking agent. The particle size, morphology of microspheres were studied using optical, scanning electron microscopy(SEM) and it was shown that microspheres gave particles in the range of 642 ± 0.07 to 720 ± 0.03μm were with more spherical shape, smooth surface and showed good flowing properties. The entrapment efficiency of microspheres was determined and had concluded that as the concentration of polymer increased, the entrapment efficiency was also increased. The entrapment efficiency of all the formulations was found to be in the range of 88.30 ± 0.01% to 89.01 ± 0.08%. The FT-IR studies showed stable character of cefixime in the drug loaded microspheres and revealed the absence of drug-polymer interaction. Data obtained from in-vitro release were fitted to various kinetic models and drug release followed zero order kinetics, the “n” value obtained from Korsmeyer-Peppas model showed that microspheres followed non-fickian drug release mechanism.
机译：该研究的目的是通过孔板离子凝胶法配制和评价头孢克肟的缓释微球。使用不同比例的药物和藻酸钠单独作为聚合物，并与共聚物（如HPMC K15M）结合使用氯化钙作为交联剂，制得了不同的制剂。用光学扫描电子显微镜（SEM）研究了微球的粒径，形貌，结果表明，在642±0.07至720±0.03μm范围内的微球具有更大的球形，光滑的表面和良好的流动性。特性。测定了微球的包封效率，并得出结论，随着聚合物浓度的增加，包封效率也增加。发现所有制剂的包封效率在88.30±0.01％至89.01±0.08％的范围内。 FT-IR研究表明，头孢克肟在载药微球中具有稳定的特性，并且表明不存在药物与聚合物的相互作用。从体外释放获得的数据适用于各种动力学模型，药物释放遵循零级动力学，从Korsmeyer-Peppas模型获得的“ n”值表明微球遵循非菲尼克斯药物释放机理。

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