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首页> 外文会议>International Conference on Food Factors(ICoFF 03); 20031201-04; Tokyo(JP) >Cancer prevention with food factors: Alone and in combination
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Cancer prevention with food factors: Alone and in combination

机译：通过食物因素预防癌症：单独使用或组合使用

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Cancer prevention strategies making use of combined agents with distinct molecular mechanisms, rather than individual agents, are considered promising for higher efficacy and lower toxicity. Although there is increasing understanding of the synergistic combinations of synthetic agents, our knowledge regarding such combinations of food factors remains limited. We recently found that free radical generation suppressants from food items in combination with their scavengers at low concentrations exhibited notable synergistic effects in activated leukocytes, whereas combinations of agents with similar modes of action showed additive or antagonistic effects. For example, (—)-epigallocatechin gallate (EGCG) from green tea has been shown to increase the endotoxin-induced production of proinflammatory mediators such as prostaglandin E_2 and tumor necrosis factor-α in RAW264.7 macrophages, whereas the soybean isoflavonoid genistein compensated for these inverse properties of EGCG, leading to marked suppression in combination. The present review briefly highlights the potential effectiveness of combinations of several agents with anti-oxidative and anti-inflammatory properties for cancer preventive strategies.
机译：使用具有不同分子机制的联合药物而不是单个药物的癌症预防策略被认为具有更高的疗效和更低的毒性。尽管人们对合成剂的增效组合有了越来越多的了解，但是我们对食物因子的这种组合的了解仍然有限。我们最近发现，食品中的自由基产生抑制剂及其低浓度的清除剂在活化的白细胞中表现出显着的协同作用，而具有相似作用方式的药物组合则表现出加和或拮抗作用。例如，绿茶中的（-）-表没食子儿茶素没食子酸酯（EGCG）已被证明能增加内毒素诱导的RAW264.7巨噬细胞中前列腺素E_2和肿瘤坏死因子-α等促炎性介质的产生，而大豆异黄酮染料木素可以补偿对于EGCG的这些逆特性，导致组合中的显着抑制。本综述简要强调了几种具有抗氧化和抗炎特性的药物组合在癌症预防策略中的潜在有效性。

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