Complexation of DNA with biocompatible diblock copolymers

机译：DNA与生物相容性二嵌段共聚物的络合

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A novel diblock copoly-mer, consisting of a biocompatible phosphorylcholine block (MPC) and a pH sensitive dimethylamino ethyl block (DMA), denoted as MPC_(30)DMA_(60), shows interesting properties of surface adsorption and solution aggregation. These features have been exploited to condense DNA into nanoaggregates in bulk solution and to immobilise DNA onto a substrate surface. These molecular manipulations may find their applications in controlled release and bionanotechnology.

机译：由生物相容性磷酸胆碱嵌段（MPC）和pH敏感的二甲基氨基乙基嵌段（DMA）组成的新型二嵌段共聚单体，表示为MPC_（30）DMA_（60），显示出有趣的表面吸附和溶液聚集特性。这些特征已被利用来将DNA浓缩成整体溶液中的纳米聚集体，并将DNA固定在基质表面上。这些分子操作可在控释和生物纳米技术中找到其应用。

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来源
《International Conference on Surface and Colloid Science; 200309; Brazil》|2003年|P.199-202|共4页
会议地点 Brazil
作者
Qing S. Mu; Ying H. Ma; Andrew L. Lewis; Steve P. Armes; Jian R. Lu;
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作者单位

Physics Department, University of Manchester Institute of Science and Technology, P.O. Box 88, Manchester, M60 1QD, UK;

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原文格式 PDF
正文语种 eng
中图分类工程材料一般性问题;
关键词
surface adsorption; nanoaggregates; DNA; neutron reflection; dynamic light scattering;

机译：表面吸附;纳米聚集体; DNA;中子反射;动态光散射;

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专利

1. DNA immobilization using biocompatible diblock phosphorylcholine copolymers [J] . Zhao XB, Zhang ZQ, Pan F, Surface and Interface Analysis: SIA: An International Journal Devoted to the Development and Application of Techniques for the Analysis of Surfaces, Interfaces and Thin Films . 2006,第4期

机译：使用生物相容性二嵌段磷酸胆碱共聚物固定DNA
2. Nickel dithiolene complexes encapsulated in biocompatible amphiphilic diblock copolymer nanoparticles [J] . Vlassi Eleni, Mousdis George A., Pispas Stergios Journal of Polymer Science, Part B. Polymer Physics . 2016,第24期

机译：二硫代镍镍络合物包封在生物相容性两亲性二嵌段共聚物纳米粒子中
3. Complexation between DNA and Hydrophilic-Cationic Diblock Copolymers [J] . Jung Seyoung, Lodge Timothy P., Reineke Theresa M. The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2017,第10期

机译：DNA和亲水 - 阳离子二嵌段共聚物之间的络合
4. Complexation of DNA with biocompatible diblock copolymers [C] . Q. S. Mu, Y. H. Ma, A. L. Lewis, International Conference on Surface and Colloid Science . 2004

机译：DNA与生物相容性二嵌段共聚物的络合
5. Synthesis of ionic boron amphiphilic diblock copolymers and pyridylborate ligands for transition metal complexes. [D] . Cui, Chengzhong. 2010

机译：离子硼两亲性二嵌段共聚物和吡啶基硼酸酯配体的合成，用于过渡金属配合物。
6. Effects of the Incorporation of a Hydrophobic Middle Block into a PEG-Polycation Diblock Copolymer on the Physicochemical and Cell Interaction Properties of the Polymer-DNA Complexes [O] . Rahul Sharma, Jae-Sung Lee, Ryan C. Bettencourt, -1

机译：将疏水性中间嵌段并入PEG-聚合二嵌段共聚物中对聚合物-DNA配合物的理化和细胞相互作用特性的影响
7. Diblock/Triblock Structural Transition and Sol-Gel Transition of Peptide/PEG Diblock Copolymer Having a Terminal Terpyridine Group Induced by Complexation with Metal Ion [O] . Satoshi Tanimoto, Yasushi Nakamura, Hitoshi Yamaoka, 2010

机译：二嵌段/三嵌段结构过渡和肽/ PEG二嵌段共聚物的溶胶 - 凝胶转化，其具有通过与金属离子络合溶液诱导的末端萜烯基团的肽/ PEG二嵌段共聚物

Complexation of DNA with biocompatible diblock copolymers

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