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首页> 外文会议>International Conference on Surface and Colloid Science; 200309; Brazil >Effect of a kosmotropic ion on doxorubicin self-assembly and interaction with biomimetic systems
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Effect of a kosmotropic ion on doxorubicin self-assembly and interaction with biomimetic systems

机译：同源离子对阿霉素自组装和仿生系统相互作用的影响

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摘要

Ions of the Hofmeister series alter water structure. Kosmo-tropes (e.g. sulfate) increase, while chaotropes decrease water structure. Hofmeister ions modulate various properties, such as the solubility and the partitioning of solutes between water and organic solvents and into model membranes. The effect of the kosmotropic ion sulfate on the self-assembly and interaction of the anticancer drug doxorubicin (DOXO) with lipid bilayers was studied by employing fluorescence spectroscopy. As expected, sulfate decreased DOXO's water solubility. In the absence of sulfate, DOXO binds more strongly to large unilamellar vesicles of the anionic phospholipid dioleoyl phosphatidyl-glycerol (DOPG) than to large unilamellar vesicles of the zwitterionic phospholipid dioleoyl phosphatidylcholine (DOPC). While increasing sulfate concentrations promoted increased DOXO binding to DOPC, the addition of salt caused an initial decrease in drug binding to DOPG, followed by an increase at higher sulfate concentrations. The results indicate that water structure effects prevail in the effect of sulfate upon DOXO solubility and partitioning into DOPC bilayers, whereas a more complex series of events contributes to the observed effect of the ion on the partitioning of the drug into DOPG bilayers.
机译：Hofmeister系列的离子会改变水的结构。 Kosmo-tropes（例如硫酸盐）增加，而离液剂则减少水的结构。霍夫迈斯特离子调节各种特性，例如溶解性和溶质在水和有机溶剂之间的分配以及进入模型膜的分配。通过荧光光谱研究了共溶离子硫酸盐对抗癌药物阿霉素（DOXO）与脂质双层的自组装和相互作用的影响。不出所料，硫酸盐降低了DOXO的水溶性。在不存在硫酸盐的情况下，DOXO与两性离子磷脂二醇油酰磷脂酰胆碱（DOPC）的大单层囊泡更牢固地结合到阴离子磷脂二油酰磷脂酰甘油（DOPG）的大单层囊泡上。尽管硫酸盐浓度的增加促进了DOXO与DOPC的结合增加，但盐的加入导致药物与DOPG的结合开始减少，随后在较高的硫酸盐浓度下增加。结果表明，水结构的影响主要体现在硫酸盐对DOXO溶解度和分配到DOPC双层中的作用，而一系列更复杂的事件有助于观察到离子对药物分配到DOPG双层中的作用。

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