首页> 外文会议>International Symposium on Eco-Materials Processing amp; Design; 20060108-11; Chengdu(CN) >Antibacterial Effect and Security Evaluation on Nano-hydroxyapatite Bearing Cu~(2+) and Zn~(2+)
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Antibacterial Effect and Security Evaluation on Nano-hydroxyapatite Bearing Cu~(2+) and Zn~(2+)

机译:纳米羟基磷灰石对Cu〜(2+)和Zn〜(2+)的抗菌作用和安全性评价

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摘要

nano-hydroxyapatite (n-HA) slurry was synthesized at normal pressure, and (Cu~(2+), Zn~(2+))-bearing nano-hydroxyapatite (Cu-Zn-HA) was prepared by ion exchange reaction in water medium. The properties of n-HA and Cu-Zn-HA were characterized by AAS, TEM, XRD and FTIR. The results of XRD analysis indicate that Cu~(2+) and Zn~(2+) can occupy Ca~(2+) sites and enter the crystal lattice of hydroxyapatite. Through the antibacterial experiments, it was found that Cu-Zn-HA had better antibacterial ability on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). After heat treatment at 400℃ for an hour, the materials still had good antibacterial effect. The accelerated aging method was employed to test antibacterial durability of the material and the results indicated that the durability was good. The results of the security assessment, including skin stimulation test of rabbit, acute toxicity test by stomach filling and the micronucleus test in bone marrow polychromatic erythrocytes of mice, showed that the security of the material was excellent.
机译:常压合成纳米羟基磷灰石(n-HA)浆料,通过离子交换反应制备含(Cu〜(2+),Zn〜(2+))的纳米羟基磷灰石(Cu-Zn-HA)。水介质。通过原子吸收光谱,透射电镜,XRD和FTIR对n-HA和Cu-Zn-HA的性质进行了表征。 XRD分析结果表明,Cu〜(2+)和Zn〜(2+)可以占据Ca〜(2+)位点并进入羟基磷灰石的晶格。通过抗菌实验,发现Cu-Zn-HA对大肠杆菌(E.coli)和金黄色葡萄球菌(S.aureus)具有更好的抗菌能力。在400℃热处理一个小时后,该材料仍具有良好的抗菌作用。采用加速老化法测试了材料的抗菌耐久性,结果表明该材料的耐久性良好。安全性评估的结果,包括对兔子的皮肤刺激试验,通过胃填充进行的急性毒性试验以及对小鼠骨髓多色红细胞的微核试验,表明该材料的安全性极好。

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