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首页> 外文会议>International symposium on polymer chemistry : Preprints. >BLOCK COPOLYMER MICELLES AND VESICLES AS NANOCARRIERS FOR GENE AND DRUG DELIVERY
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BLOCK COPOLYMER MICELLES AND VESICLES AS NANOCARRIERS FOR GENE AND DRUG DELIVERY

机译：嵌段共聚物胶束和囊泡作为基因和药物输送的纳米载体

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@@Polymeric micelles, self-assembled supramolecular structures of block copolymers, are promising nanocarrier systems for drug and gene delivery1,2). Several micellar formulations of antitumor drugs have been intensively studied in preclinical and clinical trials, and their utility has been demonstrated. Even compared with long-circulating liposomes, polymeric micelles might have several advantages, such as controlled drug release, tissue penetrating ability and reduced toxicity such as hand-foot syndrome and hypersensitivity reaction. Importantly, critical features of the polymeric micelles as drug carriers, including particle size, stability, and loading capacity and release kinetics of drugs, can be modulated by the structures and physicochemical properties of the constituent block copolymers. The development of smart polymeric micelles that dynamically change their properties due to sensitivity to chemical or physical stimuli is the most promising trend, directing to the targeting therapy with high efficacy and ensured safety.
机译：聚合物胶束，嵌段共聚物的自组装超分子结构，是用于药物和基因递送的有前途的纳米载体系统1,2）。在临床前和临床试验中已经对几种抗肿瘤药物的胶束制剂进行了深入研究，并证明了其实用性。即使与长循环脂质体相比，高分子胶束也可能具有多种优势，例如控制药物释放，组织穿透能力和降低的毒性（例如手足综合征和超敏反应）。重要的是，聚合物胶束作为药物载体的关键特征，包括粒径，稳定性，药物的负载能力和释放动力学，可以通过构成嵌段共聚物的结构和理化性质来调节。由于对化学或物理刺激的敏感性而动态改变其性能的智能聚合物胶束的发展是最有希望的趋势，这将引导靶向治疗具有高效和安全性。

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