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首页> 外文会议>International Symposium on Supercritical Fluids Tome 1: Natural Products, Process amp; Equipment Development; 20030428-20030430; Versailles; FR >SUPERCRITICAL FLUID CHROMATOGRAPHY AS SUCCESSFUL TOOL IN CHEMICAL AND PHARMACEUTICAL INDUSTRY
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SUPERCRITICAL FLUID CHROMATOGRAPHY AS SUCCESSFUL TOOL IN CHEMICAL AND PHARMACEUTICAL INDUSTRY

机译：超临界流体色谱作为化学和制药行业的成功工具

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摘要

The increasing trend towards drugs of highest purity promotes preparative-scale chromatographic techniques. Most of the separations are performed using liquid chromatography. One important advantage of using supercritical fluids instead of liquids as solvents is the reduction of organic solvents, so that no or significant less expensive solvent recovery is necessary, A high productivity of the supercritical cliromatographic process is possible because the low viscosity enables high flow rates at a moderate pressure drop and a high number of theoretical plates can be reached as a consequence of the high diffusion coefficients of supercritical fluids. At our department a large number of experimental set-ups for chromatography with supercritical fluids (SFC) at different scales and for the determination of fundamental thermodynamic data like solubilities and adsorption isotherms is available. A preparative SFC for elution mode and a Simulated Moving Bed (SMB)-SFC have been built and put into operation. A simulation tool for process optimization is available. Successful separations e.g. of phytol isomers, ibuprofen enantiomers, and tocopherol homologues were performed experimentally and by simulations. It has been shown that the supercritical fluid chromatographic technique is now ready for industrial application.
机译：朝着纯度最高的药物的增长趋势促进了制备规模的色谱技术。大多数分离是使用液相色谱进行的。使用超临界流体代替液体作为溶剂的一个重要优点是减少了有机溶剂，因此不需要或无需花费很多的钱就可以回收溶剂。超临界色谱法的高生产率是可能的，因为低粘度使得在由于超临界流体的高扩散系数，可以实现适度的压降和大量的理论塔板数。在我们的部门中，可以使用大量不同规模的超临界流体（SFC）色谱进行实验设置，并用于确定诸如溶解度和吸附等温线等基本热力学数据。用于洗脱模式的制备型SFC和模拟移动床（SMB）-SFC已建成并投入运行。提供了用于过程优化的仿真工具。成功分离例如通过实验和模拟对植物甾醇异构体，布洛芬对映异构体和生育酚同系物进行了分析。已经表明，超临界流体色谱技术现在已经准备好工业应用。

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