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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Prenatal Exposure to PM2.5 and Infant Autonomic Nervous System Reactivity: Effect Modification by Sex and Maternal Total Antioxidant Intake during Pregnancy
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Prenatal Exposure to PM2.5 and Infant Autonomic Nervous System Reactivity: Effect Modification by Sex and Maternal Total Antioxidant Intake during Pregnancy

机译：产前暴露于PM2.5和婴儿自主神经系统反应性：妊娠期性别和母体总抗氧化剂摄入量对效应的影响

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The autonomic nervous system (ANS) plays a key role in stress reactivity and is programmed during gestation. We investigated associations between prenatal exposure to fine particulate matter (PM2.5) and infant ANS reactivity during a stress challenge among 239 maternal-infant pairs enrolled in a Boston-based birth cohort. We estimated daily residential PM2.5 using satellite data in combination with land-use regression predictors. At 6 months, we measured parasympathetic nervous system (PNS) activity using continuous ECG and respiration monitoring during the repeated Still Face Paradigm (SFP-R), which is designed to elicit infant stress reactivity and regulation in response to maternal disengagement and interaction. We used multivariable linear regression to examine average PM2.5 exposure across pregnancy in relation to PNS withdrawal and activation, indexed by changes in respiratory sinus arrhythmia (RSA). We grouped infants by 'typical' or 'atypical' patterns of RSA change and used multivariable logistic regression to model associations between PM2.5 and group assignment. We examined interactions with sex and maternal total antioxidant intake during pregnancy, estimated using a food frequency questionnaire. We detected significant 3-way interactions (p<0.01 across models) between PM2.5, sex, and antioxidants. Among girls with low prenatal antioxidants (<50th percentile), each 10-unit increase in PM2.5 was associated with marginally reduced PNS withdrawal during stress (25% increase in RSA, p=0.06), marginally depressed PNS activation during recovery (24% decrease in RSA, p=0.05), and significantly increased odds of an 'atypical' response pattern (OR: 2.7, 95% CI: 1.2, 5.9). We did not observe significant findings among girls with higher prenatal antioxidants or among boys. Prenatal exposure to PM2.5 may disrupt programming of autonomic stress-response systems among girls. Higher intake of antioxidant-rich foods during pregnancy may protect against these effects.
机译：自主神经系统（ANS）在应激反应中起关键作用，并在妊娠期间进行编程。我们调查了出生于波士顿出生队列的239对母婴对应激挑战期间的产前暴露于细颗粒物（PM2.5）与婴儿ANS反应性之间的关联。我们结合卫星数据和土地利用回归预测因子来估算每日住宅PM2.5。在第6个月时，我们在重复的“ Still Face Paradigm”（SFP-R）期间使用连续ECG和呼吸监测来测量副交感神经系统（PNS）的活动，该设计旨在引起婴儿的应激反应和对母体脱离接触和互动的调节。我们使用多元线性回归分析了整个妊娠期间与PNS停药和激活相关的平均PM2.5暴露，并通过呼吸性窦性心律不齐（RSA）的变化进行了指数化。我们根据RSA变化的“典型”或“非典型”模式对婴儿进行分组，并使用多变量logistic回归对PM2.5与分组分配之间的关联进行建模。我们使用食物频率问卷调查了与性行为和孕妇孕期总抗氧化剂摄入量的相互作用。我们检测到PM2.5，性别和抗氧化剂之间存在显着的三向相互作用（模型间p <0.01）。在产前抗氧化剂水平低（<50％）的女孩中，PM2.5的每增加10个单位与压力导致的PNS撤退量减少（RSA增加25％，p = 0.06），恢复过程中的PNS激活受抑制（24）有关。 RSA减少％，p = 0.05），“非典型”应答模式的几率显着增加（OR：2.7，95％CI：1.2，5.9）。在产前抗氧化剂含量较高的女孩或男孩中，我们没有观察到重大发现。产前暴露于PM2.5可能会破坏女孩自主神经应激反应系统的程序。怀孕期间高摄入抗氧化剂含量高的食物可以预防这些影响。

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