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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >The Association between Prenatal Selenium-Related DNA Methylation Modifications in Placenta and Newborn Neurobehavioral Development: An Epigenome-Wide Study of Two U.S. Birth Cohorts
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The Association between Prenatal Selenium-Related DNA Methylation Modifications in Placenta and Newborn Neurobehavioral Development: An Epigenome-Wide Study of Two U.S. Birth Cohorts

机译：胎盘中与硒相关的DNA甲基化修饰与新生儿神经行为发育之间的关联：两个美国出生队列的表观基因组研究

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Background/Aim: As a micronutrient, selenium (Se) levels in pregnancy have been linked with the neurobehavioral development of the offspring. DNA methylation is a potential mediator of the effect of Se on neurobehavioral development; however, very few studies have investigated the role of DNA methylation in relation to prenatal Se and child neurobehavior. We aimed to investigate the associations between placental Se and epigenome-wide DNA methylation in two U.S. cohorts and to assess the association between Se-related DNA methylation modifications and children's neurobehavioral development. Methods: We measured placental Se concentration of 343 newborns enrolled in the New Hampshire Birth Cohort Study and of 141 infants in the Rhode Island Child Health Study. Genome-wide placental DNA methylation was measured by HumanMethylation450 Bead Chip, and the newborn neurobehavioral development was assessed by the NICU Network Neurobehavioral Scales. We meta-analyzed the associations between placental Se concentration and DNA methylation in each cohort, adjusting for confounders (P < 1× 10-5). We also fit multiple linear regression to assess the associations between DNA methylation and newborn neurobehavioral development. Results: We identified 25 Se-related differentially methylated CpG sites. 18 of the 25 CpG sites were positively associated with placental Se concentration. Among the 18 CpG sites, increased DNA methylation of cgl9730691 (OR [95% Confidence Interval, CI] = 0.92 [0.86, 1.00], P = 0.05) and cg09674502 (OR [95%CI] = 0.89 [0.81 0.99], P =0.03) were also associated with lower risk of high-level hypertonic responses of infants. The nearest genes to the cgl9730691 and cg09674502 are TBX15 and GFI1. Conclusions: The Se-related increase of TBXI5 and GFI1 DNA methylation were associated with beneficial motor development in infants. Future work will assess the relationship of the identified CpG sites methylation levels with childhood motor development.
机译：背景/目的：作为一种微量营养素，妊娠期硒（Se）水平与后代的神经行为发育有关。 DNA甲基化是硒对神经行为发育影响的潜在介质。然而，很少有研究调查DNA甲基化与产前硒和儿童神经行为有关。我们旨在调查两个美国队列中胎盘硒与表观基因组范围的DNA甲基化之间的关联，并评估硒相关的DNA甲基化修饰与儿童神经行为发育之间的关联。方法：我们测量了新罕布什尔州出生队列研究的343名新生儿和罗德岛儿童健康研究的141名婴儿的胎盘硒浓度。全基因组胎盘DNA甲基化通过HumanMethylation450 Bead Chip进行测量，新生儿神经行为的发育通过NICU网络神经行为量表进行评估。我们对每个队列的胎盘硒浓度与DNA甲基化之间的关联进行荟萃分析，以调整混杂因素（P <1×10-5）。我们还拟合多元线性回归，以评估DNA甲基化与新生儿神经行为发育之间的关联。结果：我们鉴定了25个硒相关的差异甲基化CpG位点。 25个CpG位点中有18个与胎盘硒浓度呈正相关。在18个CpG位点中，cgl9730691（OR [95％置信区间，CI] = 0.92 [0.86，1.00]，P = 0.05）和cg09674502（OR [95％CI] = 0.89 [0.81 0.99]，P = 0.03）也与婴儿高水平高渗反应的风险较低相关。与cgl9730691和cg09674502最接近的基因是TBX15和GFI1。结论：硒相关的TBXI5和GFI1 DNA甲基化的增加与婴儿有益的运动发育有关。未来的工作将评估已确定的CpG位点甲基化水平与儿童运动发育的关系。

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