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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Pervasive Developmental Disorder and Particulate Matter Air Pollution before, during and after Pregnancy: A Case-Cohort Study within the National Infant Medical Check-Up Cohort
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Pervasive Developmental Disorder and Particulate Matter Air Pollution before, during and after Pregnancy: A Case-Cohort Study within the National Infant Medical Check-Up Cohort

机译：怀孕之前，期间和之后的普遍性发育障碍和特定的空气污染：国家婴儿医学检查队列中的病例队列研究

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Background: There is increasing interest in the effect of air pollution in children's neurodevelopment but the evidence remains inconclusive. This study investigated the association of particulate matter air pollution exposure and pervasive developmental disorder(PDD) throughout the first 6 years of life. Methods: We conducted a case-cohort study of participants born in Korea in the year of 2008 who underwent at least the first medical check-up provided by The National Health Insurance Database until December 31, 2013. The study assessed all 761 subjects who were diagnosed with PDD till the age of six along with a subcohort of six times of that size, 5,178 subjects, selected as a 2.5% random sample of the full target cohort. Diagnosis of PDD was based on the payment and treatment data at the clinic. Daily averages of PM with diameters ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were predicted from a spatiotemporal model for South Korea and linked to residential addresses. A weighted Cox proportional hazards model was used to estimate adjusted hazard ratio (aHR) with 95% confidence intervals (CI) for PDD in infants exposed to particulate matter air pollution. Results: A significant association was found between 10 μg/m3 increment in the PM2.5 concentration and PDD with adjusted RR of 1.12 (95% CI 1.04-1.20) among the participants with the same address before and after pregnancy. Associations with PM2.5 exposure 9 months before or after the pregnancy were weaker in independent models and when all periods were included, whereas the association with the 9 months of pregnancy remained. The association between PDD and PM2.5 was stronger for exposure during the third trimester (OR = 1.32 per IQR increase in PM2.5; 95% CI: 1.16, 1.49) than during the first two. There was little association between PM10 and PDD. Conclusions: The results suggest higher maternal exposure to PM2.5 during pregnancy, particularly the third trimester, was associated with the risk of developing PDD.
机译：背景：空气污染对儿童神经发育的影响越来越引起人们的关注，但证据尚无定论。这项研究调查了生命的最初6年中颗粒物空气污染暴露与普遍性发育障碍（PDD）的关联。方法：我们对2008年出生于韩国的参与者进行了一项病例队列研究，这些参与者至少接受了国家健康保险数据库提供的首次体检，直到2013年12月31日。该研究评估了所有761名在6岁之前被诊断为PDD，并且是该规模的6倍的亚人群，共5178名受试者，被选为全部目标人群的2.5％随机样本。 PDD的诊断基于诊所的付款和治疗数据。根据韩国的时空模型预测了直径≤2.5μm（PM2.5）和≤10μm（PM10）的PM的每日平均值，并与居民地址相关联。使用加权Cox比例风险模型估计暴露于颗粒物空气污染的婴儿中PDD的调整后风险比（aHR）和95％置信区间（CI）。结果：在妊娠前后相同地址的受试者中，PM2.5浓度和PDD的增加10μg/ m3与PDD之间具有显着相关性，调整后的RR为1.12（95％CI 1.04-1.20）。在独立模型中以及包括所有时期在内，妊娠前或妊娠后9个月PM2.5暴露的关联性较弱，而妊娠9个月的关联性仍然存在。在孕晚期，PDD和PM2.5之间的关联更强（PM2.5中每IQR升高，OR = 1.32； 95％CI：1.16，1.49），比前两个时期强。 PM10和PDD之间几乎没有关联。结论：结果表明，孕妇在怀孕期间（尤其是妊娠晚期）较高的PM2.5暴露水平与发生PDD的风险有关。

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