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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Pilot Study of the Enhanced Children's Micropem Compared to the Standard Gravimetric Methods to Measure Personal Exposure and Kitchen Concentrations to Fine Particulate Matter from Household Air Pollution: HAPIN Trial Investigators
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Pilot Study of the Enhanced Children's Micropem Compared to the Standard Gravimetric Methods to Measure Personal Exposure and Kitchen Concentrations to Fine Particulate Matter from Household Air Pollution: HAPIN Trial Investigators

机译：HAPIN试验研究人员与标准重量分析方法相比，测量个人暴露量和厨房浓度以检测家庭空气污染中细颗粒物的试验研究

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Background: The HAPIN four-country randomized trial seeks to evaluate the effects of liquefied petroleum gas stoves and fuel distribution intervention on health outcomes. Adequate assessment of personal PM2.5 exposure is critical for both understanding intervention effectiveness and building exposure-response relationships. Since standard gravimetric pump and cyclone/impactor approaches for personal PM2.5 assessment are heavy, noisy, and bulky, they are unsuitable for children and burdensome to adults. In a pilot study, we compared the performance of a next-generation exposure monitor [Enhanced Children's MicroPEM (ECM), RTI International, Raleigh, NC] to standard gravimetric methods. Methods: We co-located standard gravimetric pumps and cyclone/impactors with ECMs to obtain 24- and 48-hour kitchen PM2.5 concentrations and corresponding personal exposures in Guatemala, India, Peru, and Rwanda in homes with a range of exposures. Specific sampling approaches varied across centers due to logistics. Bland-Altman plots were used to assess agreement in mean PM2.5 between devices. Results: Using 124 personal samples and 102 kitchen samples, average PM2.5 concentrations measured by standard gravimetric methods and the ECM were 97.7 pg/m3 (range: 2.1-585.9 pg/m3) and 108.5 μg/m3 (range: 9.6-516.5 μg/m3), respectively. The mean difference between the ECM and standard gravimetric approach was -10.8 μg/m3 (95% CI: -151 to 129 μg/m3). Lastly, there was no substantial proportional bias in assessment of PM2.5 concentration at any level [mean difference 0 to 49.9 μg/m3: -20.1 μg/m3 (95% CI: -96.5 to 56.2 pg/m3); mean difference 50.8 to 99.4 μg/m3: -22.2 μg/m3 (95% CI: -163.2 to 118.7 μg/m3); mean difference 107.2 to 585.9 μg/m3:10.95 μg/m3 (95% CI: -196.6 to 218.5 μg/m3)]. Conclusions: Preliminary results indicate that PM2.5 concentrations evaluated with the ECM personal exposure monitor are in agreement with those obtained with standard gravimetric samplers and cyclone/impactors.
机译：背景：HAPIN四国随机试验旨在评估液化石油气炉灶和燃料分配干预对健康结局的影响。对个人PM2.5暴露的充分评估对于理解干预效果和建立暴露-反应关系都至关重要。由于用于个人PM2.5评估的标准重量泵和旋风/撞击器方法笨重，嘈杂且笨重，因此不适合儿童使用，并且给成年人带来负担。在一项初步研究中，我们将下一代暴露监测仪[Enhanced Children's MicroPEM（ECM），RTI International，Raleigh，NC]的性能与标准重量分析方法进行了比较。方法：我们将标准重量泵和旋风除尘器/冲击器与ECM并置在一起，以在危地马拉，印度，秘鲁和卢旺达有一定暴露量的家庭中获得24小时和48小时厨房PM2.5浓度以及相应的个人暴露量。由于物流的不同，各个中心的具体抽样方法也有所不同。使用Bland-Altman图来评估设备之间平均PM2.5的一致性。结果：使用124个个人样品和102个厨房样品，通过标准重量分析法和ECM测量的平均PM2.5浓度为97.7 pg / m3（范围：2.1-585.9 pg / m3）和108.5μg/ m3（范围：9.6-516.5）微克/立方米）。 ECM和标准重量法之间的平均差为-10.8μg/ m3（95％CI：-151至129μg/ m3）。最后，在任何水平的PM2.5浓度评估中都没有实质性的比例偏差[平均差为0至49.9μg/ m3：-20.1μg/ m3（95％CI：-96.5至56.2 pg / m3）；平均差异50.8至99.4μg/ m3：-22.2μg/ m3（95％CI：-163.2至118.7μg/ m3）;平均差异107.2至585.9μg/ m3：10.95μg/ m3（95％CI：-196.6至218.5μg/ m3）]。结论：初步结果表明，使用ECM个人暴露监测仪评估的PM2.5浓度与使用标准重量采样器和旋风除尘器/撞击器获得的浓度一致。

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