• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Short-Term Effects of Fine Particulate Matter and Ozone on the Cardiac Conduction System in Patients Undergoing Cardiac Catheterization
【24h】

Short-Term Effects of Fine Particulate Matter and Ozone on the Cardiac Conduction System in Patients Undergoing Cardiac Catheterization

机译：细小颗粒物质和臭氧对正在进行心脏导管插入术的患者心脏传导系统的短期影响

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background/Aim: Air pollution-induced changes in cardiac electrophysiological properties could be a pathway linking air pollution and cardiovascular events. Yet, evidence of air pollution effects on the cardiac conduction system is incomplete. We investigated short-term effects of particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) and ozone (O3) on cardiac electrical impulse propagation and repolarization as recorded in surface electrocardiograms (ECG). Methods: We analyzed repeated 12-lead ECG measurements performed on 5,819 patients between 2001 and 2012. The participants came from the Duke CATHGEN Study who underwent cardiac catheterization and resided in North Carolina, United States (NC, U.S.). Daily concentrations of PM2.5 and O3 at each participant's home address were predicted with hybrid air quality exposure models. We used generalized additive mixed models to investigate the associations of PM2.5 and O3 with the PR interval, QRS interval, heart-rate-corrected QT interval (QTc), and heart rate (HR). The temporal lag structures of the associations were examined using distributed-lag models. Results: We observed four-day lagged increases in the PR interval of 0.17% (95%CI: 0.02%-0.33%) and 0.34% (0.10%-0.57%), respectively, by interquartile increments of PM2.5 (7.0 ug/m3) and 03 (19.4 ppb); the associations remained significant up to 7-8 days after exposure. Elevated PM2.5 was also associated with increases in the QTc interval lagged by three and four days, and increases in HR lagged by one and two days. Significant effects were found on all investigated ECG parameters when analyses were restricted to exposure levels below the current U.S. National Ambient Air Quality Standards. Conclusions: In patients undergoing cardiac catheterization, short-term exposure to air pollution was associated with a delay in atrioventricular conduction and ventricular repolarization, as well as increased heart rate. This abstract does not necessarily reflect EPA policy.
机译：背景/目的：空气污染引起的心脏电生理特性变化可能是连接空气污染和心血管事件的途径。然而，空气污染对心脏传导系统影响的证据尚不完善。我们调查了空气动力学直径（PM2.5）和臭氧（O3）中≤2.5μm的颗粒物对心脏电脉冲传播和复极化的短期影响，如表面心电图（ECG）所记录。方法：我们分析了2001年至2012年间对5,819例患者进行的12导联ECG重复测量。参与者来自Duke CATHGEN研究，该研究接受了心脏导管插入术，并居住在美国北卡罗来纳州（美国）。使用混合空气质量暴露模型预测了每个参与者住所地址的PM2.5和O3的日浓度。我们使用广义加性混合模型研究了PM2.5和O3与PR间隔，QRS间隔，经心率校正的QT间隔（QTc）和心率（HR）的关联。使用分布式滞后模型检查了关联的时间滞后结构。结果：我们观察到，四分位数的PM2.5（7.0 ug）使PR间隔四天滞后增加，分别为0.17％（95％CI：0.02％-0.33％）和0.34％（0.10％-0.57％）。 / m3）和03（19.4 ppb）；暴露后7-8天之间的关联仍然很明显。 PM2.5升高还与QTc间隔的增加滞后3天和4天以及HR滞后的增加1天和2天有关。当将分析限制在低于当前美国国家环境空气质量标准的暴露水平时，对所有调查的ECG参数均产生了显着影响。结论：在接受心脏导管检查的患者中，短期暴露于空气污染与房室传导和心室复极的延迟以及心律增加有关。此摘要不一定反映EPA政策。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号