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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Ambient Air Pollution in Relation to Diabetes and Hemoglobin A1c Biomarker in China: A Cross-Sectional Study with Findings from National Representative Data: WHO Study on Global Ageing and Adult Health (SAGE) Wave 1
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Ambient Air Pollution in Relation to Diabetes and Hemoglobin A1c Biomarker in China: A Cross-Sectional Study with Findings from National Representative Data: WHO Study on Global Ageing and Adult Health (SAGE) Wave 1

机译：与中国糖尿病和血红蛋白A1c生物标志物有关的环境空气污染：一项具有国家代表性数据的跨部门研究：世卫组织全球老龄化和成人健康研究（SAGE）第一轮

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Background: Health effects of air pollution on diabetes have been scarcely studied in developing countries. We aimed to explore the associations of long-term exposure to ambient particulate matter (PM) and N02 with diabetes prevalence and hbAlC biomarker in China. Methods: we recruited 12,116 random participants aged over 50 years from 64 cities in China as part of the WHO Study on global AGEing and adult health (SAGE) wave 1 between 2007 and 2010. For respondents who provided consent (8660), blood sample was collected then analyzed diabetes (glycosylated haemoglobin and non-fasting random blood glucose). Diabetes was defined according to the American Diabetes Association's recommendations. We calculated exposure to air pollutants using data from monitoring stations (PM with an aerodynamic diameter of 10 μm or less [PM10] and nitrogen dioxide and a spatial statistical model (PM with an aerodynamic diameter of 1 pm or less [PM1] and 2.5 pm or less [PM2.5]). We used two-level logistic regression and linear regression analyses to assess associations between exposure and outcomes, controlling for confounders. Findings Most of the studied pollutants were significantly associated with increased diabetes prevalence (eg, the adjusted odds ratios associated with an increase in IQR for PM10, PM2.5, PM1 and NO2 were 2.05, 95% CI 1.20-3.50; 1.70, 1.01-2.87, 1.01, 0.77-1.32 and 1.25, 1.00-1.50 respectively). These air pollutants were also associated with higher concentrations of fasting glucose (0.03-0.07 mmol/L). Interpretation Long-term exposure to air pollution was associated with increased risk of diabetes in older adult Chinese population.
机译：背景：发展中国家很少研究空气污染对糖尿病的健康影响。我们旨在探讨长期暴露于环境颗粒物（PM）和N02与中国糖尿病患病率和hbAlC生物标志物的关系。方法：作为2007年至2010年间WHO关于全球老龄化和成人健康（SAGE）第一波研究的一部分，我们从中国64个城市招募了12116名年龄在50岁以上的随机参与者。对于征得同意的受访者（8660）收集然后分析糖尿病（糖基化血红蛋白和非空腹随机血糖）。糖尿病是根据美国糖尿病协会的建议定义的。我们使用监测站的数据（空气动力学直径为10μm或更小的PM [PM10]和二氧化氮）和空间统计模型（空气动力学直径为1 pm或更小的[PM1]和2.5 pm的PM [PM2.5]或更少[PM2.5]。我们使用两级logistic回归和线性回归分析来评估暴露与结局之间的关联，以控制混杂因素。结果大多数研究的污染物与糖尿病患病率显着相关（例如，经调整的与PM10，PM2.5，PM1和NO2的IQR升高相关的比值比分别为2.05、95％CI 1.20-3.50、1.70、1.01-2.87、1.01、0.77-1.32和1.25、1.00-1.50。污染物还与空腹血糖浓度较高（0.03-0.07 mmol / L）有关解释长期暴露于空气污染与中国老年人群患糖尿病的风险增加有关。

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