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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Vulnerability to the Cardiovascular Effects of Ambient Heat in Six U.S. Cities: Results from the Multi-Ethnic Study of Atherosclerosis (MESA)
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Vulnerability to the Cardiovascular Effects of Ambient Heat in Six U.S. Cities: Results from the Multi-Ethnic Study of Atherosclerosis (MESA)

机译：美国六个城市对环境热对心血管的脆弱性：多族裔动脉粥样硬化研究（MESA）的结果

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Background: With climate change, temperatures are increasing. Heat-associated health events disproportionately affect certain subpopulations. However, prior research has often lacked information on individual-level health and air conditioning (AC) and neighborhood stressors/protections. Objectives: To assess whether 1) heat (two-day mean temperature above the local 75th percentile), is associated with increased heart rate and decreased blood pressure, controlling for age, time, season, daily ozone and daily particulate matter (PM2.5), and 2) associations differ by anti-hypertensive-medication use, renal function, fasting glucose, emotional support, AC ownership and use, normalized difference vegetation index, neighborhood safety and residence-specific oxides-of-nitrogen and PM2.5 exposure. Methods: Health and behavioral characteristics were obtained repeatedly on participants of the Multi-Ethnic Study of Atherosclerosis in six U.S. sites (2000-2010). These were linked with airport temperature, air quality, and satellite-and survey-derived neighborhood characteristics. We used an fixed-effects design, regressing health outcomes on linear temperature splines with knots at the city-specific 75th percentiles, interaction terms for each characteristic, and adjustment for month-of-year, age, PM2.5 and ozone. Results: For a 2-degree-Celsius increase in heat, systolic blood pressure (SBP) decreased by 1.1 mmHg (95% CI: -1.6, -0.6) and diastolic blood pressure by 0.3 mmHg (95% CI: -0.6, -0.1). Among individuals not using anti-hypertensive medications, heat-associated decreases in SBP were 2.1 mmHg greater among individuals with central AC vs. without. The remaining modifiers were not significant after multiple-comparisons corrections or in sensitivity analyses. Conclusions: Outdoor heat is associated with decreasing blood pressure, and cardiovascular vulnerability may vary primarily by central AC ownership.
机译：背景：随着气候变化，温度不断升高。与热相关的健康事件不成比例地影响某些亚群。但是，先前的研究通常缺乏有关个人健康和空调（AC）以及邻里压力源/保护措施的信息。目的：评估1）热量（高于当地第75个百分位数的两天平均温度）是否与心率升高和血压降低有关，并控制了年龄，时间，季节，每日臭氧和每日颗粒物（PM2.5） ）和2）关联因抗高血压药物的使用，肾功能，空腹血糖，情绪支持，AC拥有和使用，归一化差异植被指数，邻里安全性和居住场所特定的氮氧化物和PM2.5暴露而异。方法：在美国六个地点（2000年至2010年）的多民族动脉粥样硬化研究中反复获得健康和行为特征。这些与机场温度，空气质量以及卫星和调查得出的邻里特征有关。我们采用了固定效果设计，通过线性温度样条对健康结果进行回归分析，在城市特定的第75个百分位数处打了结，每个特征的交互作用项以及对月份，年龄，PM2.5和臭氧的调整。结果：热量每升高2摄氏度，收缩压（SBP）降低1.1 mmHg（95％CI：-1.6，-0.6），舒张压降低0.3 mmHg（95％CI：-0.6，- 0.1）。在不使用抗高血压药物的个体中，有中枢性AC的患者与没有中枢性AC的患者相比，与热相关的SBP降低大2.1 mmHg。在进行多次比较校正或敏感性分析后，其余修饰剂均不显着。结论：室外热量与血压下降有关，心血管易感性可能主要由中央空调所有者拥有。

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