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首页> 外文会议>Journal of Organ Dysfunction: ISRD 2007 Abstract Book >Association between polymorphisms of Toll-like receptor 7/8 and asthma in a southern Chinese Han Population
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Association between polymorphisms of Toll-like receptor 7/8 and asthma in a southern Chinese Han Population

机译：中国南方汉族人群Toll样受体7/8多态性与哮喘的关系

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摘要

Background: Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) of microbes in the environment and link human innate and adaptive immunity. Although TLRs are involved in the pathogenesis of asthma and atopy, there is no report about the association between TLR7 or TLR8 single nucleotide polymorphisms (SNPs) and asthma. Objectives: To evaluate the effects of TLR7/8 polymorphisms on asthma risk and asthma-related phenotypes in a southern Chinese Han Population. Methods: Genotyping of each SNP was performed using multiplex PCR in conjunction with tagged array single base extension technology. We conducted case-control and case-only association studies between the selected SNPs in TLR7/8 and asthma-related phenotypes. Results: The T allele of rs5935436 SNP in TLR7 was protective from developing asthma in males [adjusted odds ratio (ORs)=0.126,95% confidence interval (CIs)= 0.016-0.995]. The homozygote AA of rs3761623 and GG of rs3764880 were positively associated with lower forced expiratory volume in one second percentage of the predicted value (%FEV<,1>) and asthma severity in female asthmatics. These results were confirmed by haplotype analysis. Conclusion: TLR7/8 polymorphisms may play a considerable role in the pathogenesis of asthma in a gender-dependent manner. It could be clinically useful both for identifying patients at risk of asthma and for preventing its occurrence.
机译：背景：Toll样受体（TLR）识别环境中微生物的病原体相关分子模式（PAMP），并将人类的固有免疫和适应性免疫联系在一起。尽管TLR参与哮喘和特应性疾病的发病机理，但尚无关于TLR7或TLR8单核苷酸多态性（SNP）与哮喘之间关联的报道。目的：评估TLR7 / 8基因多态性对中国南方汉族人群哮喘风险和哮喘相关表型的影响。方法：使用多重PCR结合标签阵列单碱基延伸技术，对每个SNP进行基因分型。我们在TLR7 / 8中选定的SNP与哮喘相关表型之间进行了病例对照和仅病例关联研究。结果：TLR7中rs5935436 SNP的T等位基因可预防男性哮喘[调整的优势比（OR）= 0.126.95％可信区间（CI）= 0.016-0.995]。 rs3761623的纯合子AA和rs3764880的GG与较低的强制呼气量呈正相关，其占女性哮喘患者预测值的百分之一（％FEV ,, 1）和哮喘严重程度。通过单倍型分析证实了这些结果。结论：TLR7 / 8基因多态性可能以性别依赖的方式在哮喘的发病过程中发挥重要作用。它在临床上可用于识别有哮喘风险和预防哮喘发作的患者。

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  • 来源
  • 会议地点 Shanghai(CN);Shanghai(CN);Shanghai(CN);Shanghai(CN)
  • 作者

    Yao Shixuan; rnWang Zheng; rnChang Xiaoming; rnHiroyuki Wakiwaka;

  • 作者单位

    Qian Zhang@Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China--Kai-Sheng Yin@Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China--Fen-Hong Qian@Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China--Lin-Fu Zhou@Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China--Qiang Du@Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China--Ying Wang@Department of Genetics, Chinese National Human Genome Center at Shanghai, Shanghai 201203, China--Zhi-Bin Hu@Department of Epidemiology and;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng;chi
  • 中图分类 呼吸系及胸部疾病;
  • 关键词

    Asthma; Atopy; Eosinophils; Haplotype; IgE; Phenotype; Polymorphism; Sex difference; Toll like rnreceptors; X chromosome; Susceptibility;

    机译：哮喘;特应性;嗜酸性粒细胞;单倍型; IgE;表型;多态性;性别差异; Toll样受体; X染色体;易感性;

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