Separation of Blood Cells and Plasma in MicroChannel Bend Structures

机译：微通道弯曲结构中血细胞和血浆的分离

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

Biological applications of micro assay devices require easy implementable on-chip microfluidics for separation of plasma or serum from blood. This is achieved by a new blood separation technique based on a mierochannel bend structure developed within the collaborative Micro-Tele-BioChip (μTBC) project. Different prototype polymer chips have been manufactured with an UV-LIGA process and hot embossing technology. The separation mechanisms have been identified and the separation efficiency of these chips has been determined by experimental measurements using human blood samples. Results show different separation efficiencies for cells and plasma up to 100 % depending on mierochannel geometry, hematocrit, and feed velocity. This novel technique leads to an alternative blood separation method as compared to existing micro separation technologies.

机译：微量测定装置的生物学应用需要易于实施的芯片上微流体来从血液中分离血浆或血清。这是通过一项基于微通道生物芯片（μTBC）项目开发的微通道弯曲结构的新血液分离技术来实现的。已经通过UV-LIGA工艺和热压花技术制造了不同的原型聚合物芯片。已经鉴定出分离机理，并且已经通过使用人血样品的实验测量确定了这些芯片的分离效率。结果表明，取决于微通道的几何形状，血细胞比容和进料速度，细胞和血浆的分离效率最高可达100％。与现有的微分离技术相比，该新颖技术导致了另一种血液分离方法。

著录项

来源
《Lab-on-a-Chip: Platforms, Devices, and Applications》|2004年|P.143-151|共9页
会议地点 PhiladelphiaPA (US)
作者
C. Blattert; R. Jurischka; A. Schoth; P. Kerth; W. Menz;
展开▼
作者单位

Institut fuer Mikrosystemtechnik, Universitaet Freiburg, Germany;

展开▼
会议组织
原文格式 PDF
正文语种 eng
中图分类半导体技术;
关键词
bend; blood; disposable; hot embossing; lab-on-the-chip; mierochannel; microfluidic; separation; UV-LIGA; rapid prototyping;

机译：弯曲;血液;一次性使用;热压花;芯片实验室;微通道;微流控;分离; UV-LIGA;快速成型;

相似文献

外文文献
中文文献
专利

1. Centrifugal Separation Device Based on Two-Layer Laminar Flow in MicroChannels for High-Throughput and Continuous Blood Cell/Plasma Separation [J] . Taizo Kobayashi, Taisuke Funamoto, Makoto Hosaka, Japanese journal of applied physics . 2010,第7ISSUE1期

机译：基于微通道两层层流的离心分离装置，用于高通量和连续血细胞/血浆分离
2. Hydrodynamic blood cell separation using fishbone shaped microchannel for circulating tumor cells enrichment [J] . Bongseop Kwak, Sunghan Lee, Jeonghun Lee, Sensors and Actuators . 2018,第may期

机译：使用鱼骨形微通道进行血流动力学细胞分离以富集循环肿瘤细胞
3. Multiplexing slanted spiral microchannels for ultra-fast blood plasma separation [J] . Rafeie Mehdi, Zhang Jun, Asadnia Mohsen, Lab on a chip . 2016,第15期

机译：多路倾斜螺旋微通道可实现超快速血浆分离
4. Separation of blood cells and plasma in microchannel bend structures [C] . Christoph Blattert, Reinhold Jurischka, Andreas Schoth, Conference on Lab-on-a-Chip . 2004

机译：微通道弯曲结构中血细胞和等离子体的分离
5. Quantifying Expression and Loss of MiRNA in CLL B Cells and Plasma, and Modeling DEP Separation of B Cells, Plasma, and RNA From Blood [D] . Tam, Ryan Wai. 2015

机译：定量CLL B细胞和血浆中miRNA的表达和损失，并模拟血液中B细胞，血浆和RNA的DEP分离
6. Capillary flow of blood in a microchannel with differential wetting for blood plasma separation and on-chip glucose detection [O] . M. Sneha Maria, P. E. Rakesh, T. S. Chandra, 2016

机译：微通道中的毛细血管血流具有差分润湿功能用于血浆分离和片上葡萄糖检测
7. Design and Simulation of a Microfluidic Blood-Plasma Separation Chip Using Microchannel Structures [O] . Chun-ping Jen 2015

机译：微通道结构微流控等离子体分离芯片的设计与仿真

Separation of Blood Cells and Plasma in MicroChannel Bend Structures

摘要

著录项

相似文献

相关主题

期刊订阅